Jones practiced extensively Friday, and Seahawks coach Jim Mora Jr. was hopeful the nine-time Pro Bowl offensive lineman would be able to play against the 49ers. But he was one of eight players on Seattle's inactive list. Jones had microfracture surgery on his left knee last winter and missed the final four games of the 2008 season, before having a second surgery last month.
Wide receiver Deion Branch, defensive tackles Brandon Mebane and Michael Bennett, linebacker Leroy Hill and cornerback Travis Fisher were also inactive, while Mike Teel was named the Seahawks' third quarterback.
For San Francisco, wide receiver Brandon Jones was inactive after returning to practice this week after breaking his shoulder early in training camp.
Linebacker Ahmad Brooks, cornerback Marcus Hudson, safety Curtis Taylor, center Cody Wallace, wide receiver Jason Hill and defensive tackle Ricky Jean-Francois were also inactive, with Nate Davis as the third quarterback.