SANTA CLARA, Calif. -- San Francisco 49ers wide receiver Isaac Bruce, who has been dealing with a bad ankle most of the season, rolled it during practice and is questionable for Thursday night's game against the Chicago Bears.
The 16-year NFL veteran was injured Wednesday. He would be replaced by Jason Hill if necessary.
The 37-year-old Bruce has caught 20 passes for 244 yards this season. He has 1,023 receptions and 91 touchdowns in his career.
Hill has been bothered by an ankle problem as well.
Running back Glen Coffee (concussion) is out, while safety Michael Lewis (quad), tight end Vernon Davis (shoulder), tight end Delanie Walker (knee) and linebacker Takeo Spikes (shoulder) are probable.