Wood appears to be the most serious of the group. He broke his left leg on the second play of the fourth quarter and will remain in Jacksonville overnight.
The Bills already were playing with a shuffled offensive line. Starting right tackle Brad Butler was placed on injured reserve early in the year and left tackle Demetrius Bell injured his right knee last week against Tennessee. Bell was inactive Sunday.
The latest injuries forced Jonathan Scott and Jamon Meredith back on the field against the Jaguars. Scott missed practice all week following a death in his family, and Meredith sat out last week's game with a knee injury.
Lynch, meanwhile, was taken to the locker room on a cart in the second quarter. He was on the sideline in the second half in street clothes.