Pierce has missed two games since being ruled out indefinitely after an MRI exam Nov. 20 revealed the bulging disk. The Giants (6-5) decided to put Pierce on IR after he received a second opinion from Dr. Robert Watkins, an orthopedic surgeon based in Los Angeles.
The 31-year-old Pierce, in his ninth NFL season and fifth with the Giants, has 55 tackles, one sack and one forced fumble in nine games this season.
New York, which has lost five of six since opening the season 5-0, hosts rival Dallas on Sunday and is also dealing with an injury to quarterback Eli Manning, who has a stress reaction in his right foot.
Pierce played 15 games last season after appearing in all 16 games in each of the previous two seasons. He has led the Giants in tackles for the past three seasons and missed only four regular-season games since leaving the Washington Redskins to join the Giants.
He spent much of the past year in the spotlight after helping former teammate Plaxico Burress when the wide receiver accidentally shot himself in the thigh in a New York nightclub.
Pierce drove Burress to the hospital and then took the gun that Burress used back to his home in New Jersey, later arranging to get it back to the wounded receiver's home. Pierce testified before a grand jury, which declined to indict him for his role in the incident.