It's the club's first regular-season blackout since 1997 -- the year before the Bucs moved into Raymond James Stadium. Both home exhibition games were blacked out last month.
The team did not say how many tickets remained unsold at 1 p.m. Thursday, 72 hours before kickoff.
The St. Louis Rams announced Thursday that they have sold enough tickets to avoid a local blackout Sunday against the Arizona Cardinals. Also, The New York Jets, opening the new New Meadowlands Stadium, sold out their season opener against the Baltimore Ravens on Monday night.
Information from The Associated Press contributed to this report.