Indianapolis Colts president Bill Polian said Thursday that Clark -- the team's third-leading receiver -- will be out indefinitely with a wrist injury. And Austin Collie, the Colts' second-leading receiver, underwent hand surgery, the team said.
Collie is expected to be sidelined "a few weeks," a team source told ESPN NFL Insider Adam Schefter.
After spending a portion of Thursday at the Cleveland Clinic meeting with world-renowned hand specialist Dr. Thomas Graham, Clark returned to Indianapolis to meet with Polian to figure out the best course of action.
Clark is expected to need surgery on his hand/wrist and his agent, Neil Cornrich, told Schefter that his client wants to discuss the options with the Colts first. There are different recovery times and different dangers with each of the surgeries that Clark could opt to undergo. But he and the Colts soon will meet and make their decision about what is best for him.
"He's going to talk to Bill Polian and they'll reach a decision," Cornrich said. "But he's comfortable."
Polian, speaking at an event in Fort Wayne, Ind., told the audience that Clark has "an injury to his wrist, which is a relatively rare injury," the Indianapolis Star reported.
Clark has 37 receptions for 347 yards and three touchdowns this season. Collie is second on the Colts with 503 yards and his six touchdowns lead the team. His 44 receptions rank one behind team leader Reggie Wayne.
The Colts also announced defensive tackle Antonio Johnson had surgery on his knee. No timetable for his return has been set.
Wednesday, the Colts re-signed tight end Gijon Robinson, who was waived earlier this year.
Information from The Associated Press was used in this report.