Jackson is fifth in the NFL with 617 yards rushing. He broke the finger in last week's 18-17 loss in Tampa.
Carolina Panthers running back DeAngelo Williams was inactive for the game. Williams left the field in the final minute of Carolina's win over San Francisco 49ers last weekend and didn't practice all week.
Williams rushed for more than 1,100 yards last season and was a Pro Bowl selection. He has 361 yards on 87 carries in 2010.
Jonathan Stewart will start at running back for Carolina.