Mike Sims-Walker out with ankle injury
Sims-Walker, who has 32 catches for 418 yards and four touchdowns, sprained his right ankle last week against Houston and missed two days of practice this week. He was limited in practice Friday, but his ankle was still sore and swollen.
Without Sims-Walker, Tiquan Underwood will make his first career start.
Kick returner Deji Karim also is inactive for the Jaguars.
Copyright 2010 by The Associated Press