The team announced Saturday that Samuel wasn't making the trip to Chicago. He injured his knee while recovering a fumble in a 27-17 win last weekend against the New York Giants.
Samuel missed one game earlier this season with a concussion. He leads the NFL with seven interceptions, including four against the Manning brothers.
The NFC-East leading Eagles (7-3) have a quick turnaround after playing the Bears (7-3). They host Houston Thursday night.