"I think it will be a stretch for him to play in this game," Philadelphia coach Andy Reid said.
The Eagles listed Vick as questionable on their official injury report. Sunday's home game has no significance to Philadelphia's playoff status.
Vick bruised his right leg on the first play of the Eagles' 24-14 loss to the Vikings Tuesday night, a loss that eliminated the Eagles from contention for a first-round playoff bye and locked them into the No. 3 seed in the NFC playoffs as the East division champions.
The Eagles (10-5) will open the postseason against either the Packers, Giants or Buccaneers.
Kevin Kolb, who has started four games, will start Sunday if Vick can't go. The Eagles are 8-3 this year when Vick starts and 2-2 with Kolb, who was the opening-day starter.
Reid said Kolb took all of the practice reps with the starting offense Thursday and Friday.
Vick, who missed the 2007 and 2008 seasons while in prison after pleading guilty to federal dogfighting charges, was selected to the Pro Bowl for the first time in five years after leading the Eagles to their first NFC East title since 2006.
He's thrown 21 touchdowns and six interceptions, passed for 3,018 yards and rushed for 676.
"He's been in with [trainer] Rick [Burkholder] and getting everything done that needs to be done," Reid said.
Vick missed three games in October with a rib injury. Both of Vick's injuries came on running plays.
Reid said he's not concerned that Vick is putting himself at risk by scrambling too much.
"This did happen on a run, [but] this was a little different," Reid said. "This wasn't a big hit or any of that. Actually, it was just somebody's elbow caught him ... between the slide pad and the knee pad, so kind of a freak deal.
"I think he's been doing better at getting down, and he's been working on getting out of bounds, doing those things so this wouldn't happen. This one, actually, he was diving down and he got out of the way of a big hit."
Kolb hasn't played since the Eagles lost to the Titans in Nashville on Oct. 24.
"The more reps you get, the more comfortable you feel, especially for a guy like me who hasn't played in a while," Kolb said. "We have to make sure that we're right for the playoffs, and it starts with us as backups doing the right thing on Sunday."