Brees is becoming a staple on this list. He completed 26 of 30 passes (87 percent) for 320 yards and three touchdowns to lead the Saints to a much-needed 34-3 victory over the Raiders. Brees now has six 300-yards-plus passing games this season, including four straight, and 1,993 yards.
A crisp and efficient offensive attack helped the Colts finally earn their first victory at their new stadium. Manning completed 19 of 28 passes for 271 yards and three TDs as the Colts dismantled the Ravens 31-3. It was Manning's first three-TD game of the season.
Johnson caught 10 passes for 178 yards and one TD in Houston's dramatic 29-28 victory over the Dolphins. His biggest catch came late in the fourth quarter, when Johnson kept alive what turned out to be the game-winning drive with a spectacular 23-yard catch on fourth-and-10. Johnson also had a 61-yard reception -- his longest of the season.
The Redskins' winning streak was snapped at four, but Portis continues to roll. He rushed for 129 yards on 21 carries -- his third straight 100-yard game -- and had two TDs in a 19-17 loss to St. Louis. Portis' 2-yard TD run with 3:47 remaining gave Washington a 17-16 lead.
Jones ran for two touchdowns, including a 1-yarder late in the game, and caught a 2-yard TD pass from Brett Favre to key the Jets' 26-14 victory over the Bengals. Jones finished with 17 carries for 65 yards as New York improved to 3-0 in games immediately following a bye under coach Eric Mangini.
In a physical, hard-fought game at Denver, the Jaguars leaned on Jones-Drew to do the heavy lifting. Jones-Drew rushed for a season-high 125 yards and two TDs on 22 carries to power Jacksonville to a 24-17 victory.
Often overshadowed by star teammates Larry Fitzgerald and Anquan Boldin, Breaston grabbed the spotlight Sunday. Breaston had eight catches for 102 yards and one TD in the Cardinals' 30-24 overtime victory over Dallas.
New England's defense had no answer for Rivers and the Chargers' offense. Rivers completed 18 of 27 passes for 306 yard and three TDs in San Diego's 30-10 win. Rivers' first TD pass was a 49-yarder to Malcolm Floyd. He also had a 59-yard completion to Vincent Jackson in the third quarter.
Williams' roller-coaster season continues. In Week 5, he rushed for 123 yards and had three TDs in the Panthers' victory over the Chiefs. On Sunday, Williams was held to 27 yards on 11 carries and did not score in a 27-3 loss to the Bucs. It was Williams' second 27-yard rushing game of the season.
After not throwing more than one interception in any game this season, Delhomme was picked off three times in Carolina's loss at Tampa Bay. The Carolina quarterback entered the game 7-1 versus Tampa Bay, including 4-0 at Raymond James Stadium, where the Panthers had not lost in five trips since 2002 -- the year the NFC South was formed.
In the same game in which Brees thrived, Russell struggled mightily. The Raiders' QB completed only 13 of 35 passes for 159 yards while throwing an interception and fumbling. Russell also threw six other incompletions that were nearly interceptions. Two were dropped by safety Roman Harper.
Things keep getting worse for the Bengals' offense. The Bengals' leading rusher in Sunday's loss to the Jets was QB Ryan Fitzpatrick (23 yards). Feature back Chris Perry was held to 14 yards on 11 carries as Cincinnati rushed for only 43 yards as a team on 21 carries (a 2-yard average).
Forced to play third-string QB Charlie Frye because of injuries, the Seahawks' offense never found its rhythm in a 27-17 loss to the Packers. Seattle mustered only 177 yards of total offense; Frye was held to 83 yards passing and was intercepted twice.