Final

49ers 37

(1-0, 1-0 away)

Colts 17

(0-1, 0-1 home)

1:00 PM ET, August 15, 2010

Lucas Oil Stadium, Indianapolis, IN 

1 2 3 4 T
SF 0 20 7 1037
IND 10 0 0 717

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INDIANAPOLIS, IN - AUGUST 15: Peyton Manning #18 of the Indianapolis Colts drops back to pass during the preseason game against the San Francisco 49ers at Lucas Oil Stadium on August 15, 2010 in Indianapolis, Indiana. (Photo by Scott Boehm/Getty Images)