| 1st Quarter | | HOU | BUF |
| | R.Lindell kicks 65 yards from BUF 30 to HST 5. A.Davis MUFFS catch, and recovers at HST 5. A.Davis to HST 16 for 11 yards (N.Harris). | | |
| |
| Houston Texans at 15:00 | HOU | BUF |
| 1st and 10 at HOU 16 | M.Schaub scrambles pushed ob at HST 18 for 2 yards (R.Corner). | | |
| 2nd and 8 at HOU 18 | M.Schaub pass short middle to O.Daniels to HST 40 for 22 yards (G.Wilson, J.Byrd). Caught at HST 32, slanting from left. | | |
| 1st and 10 at HOU 40 | M.Schaub pass short right to S.Slaton pushed ob at HST 45 for 5 yards (T.McGee). Dump pass, caught at HST 35. | | |
| 2nd and 5 at HOU 45 | J.Jones right end pushed ob at BUF 38 for 17 yards (J.Byrd). Reverse, handoff from M.Schaub. | | |
| 1st and 10 at BUF 38 | R.Moats left end pushed ob at BUF 32 for 6 yards (P.Posluszny). | | |
| 2nd and 4 at BUF 32 | M.Schaub pass deep left intended for O.Daniels INTERCEPTED by J.Byrd [G.Wilson] at BUF 13. J.Byrd to BUF 13 for no gain (O.Daniels). | | |
| DRIVE TOTALS: HOU 0, BUF 0, 5 plays, 52 yards, 2:43 elapsed |
| |
| Buffalo Bills at 12:17 | HOU | BUF |
| 1st and 10 at BUF 13 | R.Fitzpatrick pass short left to J.Reed to BUF 17 for 4 yards (E.Wilson). Flat pass, caught at BUF 17. | | |
| 2nd and 6 at BUF 17 | M.Lynch right tackle pushed ob at BUF 25 for 8 yards (J.Reeves). | | |
| 1st and 10 at BUF 25 | M.Lynch right guard to BUF 33 for 8 yards (G.Quin, Du.Robinson). | | |
| 2nd and 2 at BUF 33 | M.Lynch right tackle to BUF 32 for -1 yards (Du.Robinson, B.Cushing). | | |
| 3rd and 3 at BUF 32 | R.Fitzpatrick pass incomplete short left to J.Reed. Overthrown, receiver near sideline at BUF 35. | | |
| 4th and 3 at BUF 32 | B.Moorman punts 48 yards to HST 20, Center-G.Sanborn. J.Jones to HST 31 for 11 yards (J.Wendling, C.Draft). | | |
| DRIVE TOTALS: HOU 0, BUF 0, 5 plays, 19 yards, 2:21 elapsed |
| |
| Houston Texans at 9:43 | HOU | BUF |
| 1st and 10 at HOU 31 | S.Slaton up the middle to HST 32 for 1 yard (M.Stroud, G.Wilson). | | |
| 2nd and 9 at HOU 32 | (Shotgun) M.Schaub pass short right to K.Walter to HST 35 for 3 yards (C.Kelsay). Screen pass, caught at HST 33. | | |
| 3rd and 6 at HOU 35 | (Shotgun) M.Schaub pass incomplete deep right to K.Walter [A.Schobel]. HST-O.Daniels was injured during the play. Underthrown, receiver along sideline at BUF 45. O.Daniels assisted off. | | |
| 4th and 6 at HOU 35 | M.Turk punts 39 yards to BUF 26, Center-J.Dreessen, fair catch by F.Jackson. | | |
| DRIVE TOTALS: HOU 0, BUF 0, 3 plays, 4 yards, 1:21 elapsed |
| |
| Buffalo Bills at 8:13 | HOU | BUF |
| 1st and 10 at BUF 26 | R.Fitzpatrick pass short middle to T.Owens to BUF 29 for 3 yards (Z.Diles, S.Cody) [M.Williams]. BUF-J.Meredith was injured during the play. Caught in coverage at BUF 29. J.Meredith assisted off. | | |
| 2nd and 7 at BUF 29 | M.Lynch up the middle to BUF 29 for no gain (D.Ryans, B.Cushing). | | |
| 3rd and 7 at BUF 29 | (Shotgun) R.Fitzpatrick pass short left to St.Johnson pushed ob at BUF 34 for 5 yards (B.Cushing). Caught along sideline at BUF 34. | | |
| 4th and 2 at BUF 34 | B.Moorman punts 61 yards to HST 5, Center-G.Sanborn. J.Jones to BUF 25 for 70 yards (T.Johnson). Return credited to BUF 43 (spot of foul). PENALTY on HST-Z.Diles, Offensive Holding, 10 yards, enforced at BUF 43. | | |
| DRIVE TOTALS: HOU 0, BUF 0, 3 plays, 8 yards, 2:04 elapsed |
| |
| Houston Texans at 6:09 | HOU | BUF |
| 1st and 10 at HOU 47 | M.Schaub pass incomplete short left to A.Johnson. Thrown wide of receiver at BUF 49, slanting to middle. | | |
| 2nd and 10 at HOU 47 | (Shotgun) M.Schaub pass short left to A.Johnson to BUF 47 for 6 yards (Sp.Johnson, C.Draft). Screen pass, caught at HST 45. | | |
| 3rd and 4 at BUF 47 | (Shotgun) M.Schaub pass short left to S.Slaton to BUF 40 for 7 yards (P.Posluszny). FUMBLES (P.Posluszny), RECOVERED by BUF-M.Stroud at BUF 42. | | |
| DRIVE TOTALS: HOU 0, BUF 0, 2 plays, 6 yards, 0:54 elapsed |
| |
| Buffalo Bills at 5:15 | HOU | BUF |
| 1st and 10 at BUF 42 | F.Jackson right guard to BUF 45 for 3 yards (B.Pollard, D.Ryans). | | |
| 2nd and 7 at BUF 45 | F.Jackson up the middle to BUF 49 for 4 yards (J.Zgonina, Z.Diles). | | |
| 3rd and 3 at BUF 49 | R.Fitzpatrick sacked at BUF 41 for -8 yards (B.Cushing). | | |
| 4th and 11 at BUF 41 | B.Moorman punts 43 yards to HST 16, Center-G.Sanborn. J.Jones pushed ob at HST 30 for 14 yards (J.Wendling). Return credited to HST 29 (spot of foul). PENALTY on HST-D.Barber, Illegal Block Above the Waist, 10 yards, enforced at HST 29. J.Jones: 76 punt ret. yds. today, new Texans record (old record was 73, Jacoby Jones, 10/26/08) | | |
| DRIVE TOTALS: HOU 0, BUF 0, 3 plays, -1 yards, 1:37 elapsed |
| |
| Houston Texans at 3:25 | HOU | BUF |
| 1st and 10 at HOU 19 | R.Moats right tackle to HST 25 for 6 yards (P.Posluszny, A.Schobel). | | |
| 2nd and 4 at HOU 25 | M.Schaub pass short middle intended for A.Johnson INTERCEPTED by J.Byrd at HST 38. J.Byrd to HST 29 for 9 yards (K.Walter). | | |
| DRIVE TOTALS: HOU 0, BUF 0, 1 plays, 15 yards, 0:35 elapsed |
| |
| Buffalo Bills at 2:40 | HOU | BUF |
| 1st and 10 at HOU 29 | T.Owens left end for 29 yards, TOUCHDOWN. End-around, handoff from R.Fitzpatrick. Key block: L.Evans. | 0 | 6 |
| R.Lindell extra point is GOOD, Center-G.Sanborn, Holder-B.Moorman. | 0 | 7 |
| | R.Lindell kicks 65 yards from BUF 35 to HST 0. A.Davis to HST 26 for 26 yards (A.Palmer, R.Denney). | | |
| DRIVE TOTALS: HOU 0, BUF 7, 1 play, 29 yards, 0:00 elapsed |
| |
| Houston Texans at 2:31 | HOU | BUF |
| 1st and 10 at HOU 26 | M.Schaub pass short middle to A.Johnson to HST 38 for 12 yards (D.Florence). Caught at HST 38, slanting from left. | | |
| 1st and 10 at HOU 38 | R.Moats left guard to BUF 48 for 14 yards (G.Wilson, J.Byrd). | | |
| 1st and 10 at BUF 48 | M.Schaub pass incomplete short right to A.Johnson. Underthrown, receiver in flat at BUF 44. Pressure on QB: C.Kelsay. | | |
| 2nd and 10 at BUF 48 | (Shotgun) M.Schaub scrambles up the middle to BUF 40 for 8 yards (R.Corner). PENALTY on BUF-R.Corner, Unnecessary Roughness, 15 yards, enforced at BUF 40. | | |
| 1st and 10 at BUF 25 | M.Schaub sacked at BUF 36 for -11 yards (A.Schobel). | | |
| 2nd and 21 at BUF 36 | M.Schaub pass short left to D.Anderson to BUF 29 for 7 yards (D.Florence). Caught near sideline at BUF 33. Pressure on QB: A.Schobel. | | |
| End of Period | | |
| DRIVE TOTALS: HOU 0, BUF 7, 8 plays, 42 yards, 2:42 elapsed |
Houston 31, 
Buffalo 10