| 1st Quarter | | SFO | IND |
| | P.McAfee kicks 64 yards from IND 30 to SF 6. M.Robinson to SF 29 for 23 yards (F.Keiaho). | | |
| |
| San Francisco 49ers at 15:00 | SFO | IND |
| 1st and 10 at SF 29 | (Run formation) F.Gore up the middle to SF 35 for 6 yards (C.Session, B.Sanders). SF-J.Staley was injured during the play. | | |
| 2nd and 4 at SF 35 | Direct snap to #21 F. Gore (Shotgun) F.Gore up the middle to SF 36 for 1 yard (A.Bethea). | | |
| 3rd and 3 at SF 36 | (Shotgun) A.Smith pass incomplete short left to V.Davis. | | |
| 4th and 3 at SF 36 | A.Lee punts 51 yards to IND 13, Center-B.Jennings. J.Silva to IND 13 for no gain (A.Battle). FUMBLES (A.Battle), and recovers at IND 13. J.Silva to IND 15 for 2 yards (G.Coffee). | | |
| DRIVE TOTALS: SF 0, IND 0, 3 plays, 8 yards, 1:24 elapsed |
| |
| Indianapolis Colts at 13:23 | SFO | IND |
| 1st and 10 at IND 15 | (Run formation) P.Manning pass incomplete deep right to P.Garcon. | | |
| 2nd and 10 at IND 15 | J.Addai right end to IND 19 for 4 yards (M.Lawson, J.Smith). | | |
| 3rd and 6 at IND 19 | (Shotgun) P.Manning pass short left to D.Clark to IND 24 for 5 yards (D.Goldson). FUMBLES (D.Goldson), RECOVERED by SF-S.Spencer at IND 27. S.Spencer to IND 27 for no gain (Ch.Johnson). Indianapolis challenged the fumble ruling, and the play was REVERSED. (Shotgun) P.Manning pass short left to D.Clark to IND 23 for 4 yards (D.Goldson). | | |
| 4th and 2 at IND 23 | P.McAfee punts 48 yards to SF 29, Center-J.Snow. N.Clements to SF 29 for no gain (P.Wheeler, A.Francisco). PENALTY on IND-P.Wheeler, Ineligible Downfield Kick, 5 yards, enforced at IND 23 - No Play. | | |
| 4th and 7 at IND 18 | P.McAfee punts 60 yards to SF 22, Center-J.Snow. N.Clements to SF 30 for 8 yards (J.Silva, F.Keiaho). | | |
| DRIVE TOTALS: SF 0, IND 0, 3 plays, 9 yards, 1:08 elapsed |
| |
| San Francisco 49ers at 12:02 | SFO | IND |
| 1st and 10 at SF 30 | A.Smith pass short right to I.Bruce to SF 36 for 6 yards (K.Hayden, T.Hagler). | | |
| 2nd and 4 at SF 36 | F.Gore up the middle for 64 yards, TOUCHDOWN. | 6 | 0 |
| J.Nedney extra point is GOOD, Center-B.Jennings, Holder-A.Lee. | 7 | 0 |
| | J.Nedney kicks 64 yards from SF 30 to IND 6. C.Simpson to IND 22 for 16 yards (M.Hudson). | | |
| DRIVE TOTALS: SF 7, IND 0, 2 plays, 70 yards, 0:46 elapsed |
| |
| Indianapolis Colts at 11:16 | SFO | IND |
| 1st and 10 at IND 22 | P.Manning pass short right to J.Addai to IND 24 for 2 yards (A.Franklin, M.Lawson). | | |
| 2nd and 8 at IND 24 | J.Addai right end to IND 30 for 6 yards (M.Lewis). | | |
| 3rd and 2 at IND 30 | (Shotgun) P.Manning pass incomplete short left to R.Wayne (D.Bly). | | |
| 4th and 2 at IND 30 | P.McAfee punts 43 yards to SF 27, Center-J.Snow, fair catch by N.Clements. | | |
| DRIVE TOTALS: SF 7, IND 0, 3 plays, 8 yards, 1:36 elapsed |
| |
| San Francisco 49ers at 9:32 | SFO | IND |
| 1st and 10 at SF 27 | (Pass formation) A.Smith sacked at SF 24 for -3 yards (A.Johnson). | | |
| 2nd and 13 at SF 24 | F.Gore up the middle to SF 23 for -1 yards (G.Brackett). | | |
| 3rd and 14 at SF 23 | (Shotgun) A.Smith pass incomplete short left to F.Gore [R.Mathis]. | | |
| 4th and 14 at SF 23 | A.Lee punts 59 yards to IND 18, Center-B.Jennings. J.Silva to IND 23 for 5 yards (A.Battle, A.Lee). | | |
| DRIVE TOTALS: SF 7, IND 0, 3 plays, -4 yards, 1:30 elapsed |
| |
| Indianapolis Colts at 7:56 | SFO | IND |
| 1st and 10 at IND 23 | P.Manning pass incomplete short left to R.Wayne. Play stopped for SF J. Powers (25); lost shoe. | | |
| 2nd and 10 at IND 23 | J.Addai left tackle to IND 25 for 2 yards (J.Smith, I.Sopoaga). | | |
| 3rd and 8 at IND 25 | (Shotgun) P.Manning pass short right to R.Wayne pushed ob at SF 43 for 32 yards (S.Spencer). | | |
| 1st and 10 at SF 43 | (Shotgun) P.Manning pass incomplete deep left to R.Wayne. | | |
| 2nd and 10 at SF 43 | J.Addai right end to SF 42 for 1 yard (T.Spikes). | | |
| 3rd and 9 at SF 42 | (Shotgun) P.Manning pass short left to A.Collie to SF 28 for 14 yards (D.Bly) [T.Brown]. | | |
| 1st and 10 at SF 28 | J.Addai right end pushed ob at SF 25 for 3 yards (M.Lewis). PENALTY on IND-P.Garcon, Offensive Holding, 10 yards, enforced at SF 28 - No Play. | | |
| 1st and 20 at SF 38 | P.Manning pass incomplete deep left to R.Wayne (S.Spencer). | | |
| 2nd and 20 at SF 38 | (Shotgun) P.Manning pass short left to D.Clark to SF 20 for 18 yards (D.Goldson). | | |
| 3rd and 2 at SF 20 | J.Addai right tackle to SF 20 for no gain (K.Balmer). | | |
| 4th and 2 at SF 20 | M.Stover 38 yard field goal is GOOD, Center-J.Snow, Holder-P.McAfee. | 7 | 3 |
| P.McAfee kicks 70 yards from IND 30 to SF 0. M.Robinson to SF 12 for 12 yards (J.Silva). | | |
| DRIVE TOTALS: SF 7, IND 3, 10 plays, 57 yards, 4:40 elapsed |
| |
| San Francisco 49ers at 3:16 | SFO | IND |
| 1st and 10 at SF 12 | F.Gore up the middle to SF 15 for 3 yards (C.Session, G.Brackett). | | |
| 2nd and 7 at SF 15 | A.Smith pass short right to I.Bruce to SF 28 for 13 yards (B.Sanders). | | |
| 1st and 10 at SF 28 | A.Smith pass incomplete short left to M.Crabtree. | | |
| 2nd and 10 at SF 28 | A.Smith pass short right to M.Crabtree pushed ob at SF 40 for 12 yards (K.Hayden). | | |
| 1st and 10 at SF 40 | A.Smith pass deep right intended for M.Crabtree INTERCEPTED by B.Sanders at IND 37. B.Sanders to SF 34 for 29 yards (C.Rachal). | | |
| DRIVE TOTALS: SF 7, IND 3, 4 plays, 57 yards, 2:09 elapsed |
| |
| Indianapolis Colts at 1:07 | SFO | IND |
| 1st and 10 at SF 34 | (Shotgun) P.Manning pass short left to R.Wayne to SF 21 for 13 yards (S.Spencer). | | |
| 1st and 10 at SF 21 | J.Addai left tackle to SF 21 for no gain (A.Franklin). | | |
| 2nd and 10 at SF 21 | P.Manning pass short left to R.Wayne pushed ob at SF 15 for 6 yards (S.Spencer). | | |
| DRIVE TOTALS: SF 7, IND 3, 5 plays, 19 yards, 1:17 elapsed |
San Francisco 14, 
Indianapolis 18