| 1st Quarter | | HOU | IND |
| | K.Brown kicks 76 yards from HST 30 to IND -6. C.Simpson, Touchback. | | |
| |
| Indianapolis Colts at 15:00 | HOU | IND |
| 1st and 10 at IND 20 | P.Manning pass short left to D.Clark to IND 23 for 3 yards (E.Wilson). | | |
| 2nd and 7 at IND 23 | (No Huddle, Shotgun) P.Manning pass short right to D.Clark to IND 34 for 11 yards (B.Pollard, J.Reeves). | | |
| 1st and 10 at IND 34 | (No Huddle, Shotgun) P.Manning pass short right to P.Garcon to IND 39 for 5 yards (B.Cushing, D.Ryans). | | |
| 2nd and 5 at IND 39 | (No Huddle, Shotgun) P.Manning pass short left to A.Collie to IND 49 for 10 yards (G.Quin). | | |
| 1st and 10 at IND 49 | (No Huddle, Shotgun) P.Manning pass short left to D.Clark to HST 41 for 10 yards (G.Quin). | | |
| 1st and 10 at HOU 41 | (No Huddle, Shotgun) J.Addai right tackle to HST 37 for 4 yards (T.Jamison, J.Zgonina). | | |
| 2nd and 6 at HOU 37 | (No Huddle, Shotgun) P.Manning pass incomplete short middle to A.Collie (G.Quin). | | |
| 3rd and 6 at HOU 37 | (Shotgun) P.Manning pass incomplete short right to A.Collie (G.Quin). | | |
| 4th and 6 at HOU 37 | (Punt formation) PENALTY on HST-K.Bentley, Defensive Offside, 5 yards, enforced at HST 37 - No Play. | | |
| 4th and 1 at HOU 32 | (Run formation) P.Manning pass incomplete deep right to J.Addai. | | |
| DRIVE TOTALS: HOU 0, IND 0, 9 plays, 48 yards, 2:09 elapsed |
| |
| Houston Texans at 12:51 | HOU | IND |
| 1st and 10 at HOU 32 | M.Schaub sacked at HST 29 for -3 yards (D.Freeney). | | |
| 2nd and 13 at HOU 29 | (Shotgun) M.Schaub pass short left to A.Johnson to HST 30 for 1 yard (D.Freeney, A.Bethea). | | |
| 3rd and 12 at HOU 30 | (Run formation) M.Schaub pass short right to S.Slaton to HST 37 for 7 yards (C.Session). | | |
| 4th and 5 at HOU 37 | M.Turk punts 42 yards to IND 21, Center-J.Dreessen, fair catch by T.Rushing. | | |
| DRIVE TOTALS: HOU 0, IND 0, 3 plays, 5 yards, 1:44 elapsed |
| |
| Indianapolis Colts at 10:59 | HOU | IND |
| 1st and 10 at IND 21 | D.Clark right end to IND 25 for 4 yards (D.Ryans, B.Pollard). | | |
| 2nd and 6 at IND 25 | (Shotgun) P.Manning pass short left to R.Wayne to IND 32 for 7 yards (G.Quin). | | |
| 1st and 10 at IND 32 | (Shotgun) P.Manning pass short right to D.Clark to IND 43 for 11 yards (B.Cushing). | | |
| 1st and 10 at IND 43 | (Shotgun) P.Manning pass incomplete deep right to P.Garcon. | | |
| 2nd and 10 at IND 43 | (Shotgun) P.Manning pass short left to J.Addai pushed ob at 50 for 7 yards (G.Quin). | | |
| 3rd and 3 at 50 | (Shotgun) P.Manning pass incomplete short left to R.Wayne. PENALTY on HST-Du.Robinson, Defensive Pass Interference, 7 yards, enforced at 50 - No Play. | | |
| 1st and 10 at HOU 43 | (Shotgun) P.Manning pass short right to J.Addai to HST 25 for 18 yards (G.Quin, D.Ryans). | | |
| 1st and 10 at HOU 25 | (Shotgun) PENALTY on IND-R.Diem, False Start, 5 yards, enforced at HST 25 - No Play. | | |
| 1st and 15 at HOU 30 | C.Simpson left end to HST 28 for 2 yards (D.Ryans). | | |
| 2nd and 13 at HOU 28 | (Shotgun) P.Manning pass short left to D.Clark to HST 21 for 7 yards (E.Wilson). | | |
| 3rd and 6 at HOU 21 | (Shotgun) P.Manning pass short right to D.Clark to HST 14 for 7 yards (B.Cushing). | | |
| 1st and 10 at HOU 14 | (Shotgun) J.Addai up the middle to HST 14 for no gain (T.Bulman). | | |
| 2nd and 10 at HOU 14 | P.Manning pass short right to P.Garcon to HST 7 for 7 yards (B.Pollard, B.Cushing). | | |
| 3rd and 3 at HOU 7 | (Shotgun) P.Manning pass short middle to J.Addai for 7 yards, TOUCHDOWN. | 0 | 6 |
| M.Stover extra point is GOOD, Center-J.Snow, Holder-P.McAfee. | 0 | 7 |
| | P.McAfee kicks 63 yards from IND 30 to HST 7. J.Jones to HST 28 for 21 yards (P.McAfee). | | |
| DRIVE TOTALS: HOU 0, IND 7, 12 plays, 81 yards, 4:39 elapsed |
| |
| Houston Texans at 6:11 | HOU | IND |
| 1st and 10 at HOU 28 | M.Schaub pass deep left intended for A.Johnson INTERCEPTED by J.Powers at HST 46. J.Powers to HST 45 for 1 yard (A.Johnson). | | |
| DRIVE TOTALS: HOU 0, IND 7, 1 play, 0 yards, 0:00 elapsed |
| |
| Indianapolis Colts at 6:04 | HOU | IND |
| 1st and 10 at HOU 45 | (Shotgun) P.Manning pass deep right to P.Garcon to HST 19 for 26 yards (J.Reeves). Penalty on HST-B.Pollard, Illegal Contact, declined. | | |
| 1st and 10 at HOU 19 | (Shotgun) J.Addai right guard to HST 13 for 6 yards (B.Pollard). | | |
| 2nd and 4 at HOU 13 | (Shotgun) P.Manning sacked at HST 20 for -7 yards (B.Cushing). PENALTY on HST-A.Smith, Defensive Offside, 5 yards, enforced at HST 13 - No Play. | | |
| 1st and 8 at HOU 8 | P.Manning pass short left to P.Garcon to HST 4 for 4 yards (E.Wilson). PENALTY on HST-M.Williams, Defensive Offside, 4 yards, enforced at HST 8 - No Play. | | |
| 1st and 4 at HOU 4 | J.Addai right tackle to HST 5 for -1 yards (B.Cushing). | | |
| 2nd and 5 at HOU 5 | (Shotgun) P.Manning pass incomplete short right to J.Addai. | | |
| 3rd and 5 at HOU 5 | (Shotgun) P.Manning pass short left to R.Wayne to HST 4 for 1 yard (Du.Robinson). Penalty on IND-A.Collie, Offensive Pass Interference, declined. | | |
| 4th and 4 at HOU 4 | M.Stover 22 yard field goal is GOOD, Center-J.Snow, Holder-P.McAfee. | 0 | 10 |
| P.McAfee kicks 73 yards from IND 30 to HST -3. J.Jones to HST 21 for 24 yards (R.Humber, F.Keiaho). PENALTY on IND-C.Glenn, Personal Foul, 15 yards, enforced at HST 21. | | |
| DRIVE TOTALS: HOU 0, IND 10, 6 plays, 41 yards, 2:07 elapsed |
| |
| Houston Texans at 3:57 | HOU | IND |
| 1st and 10 at HOU 36 | R.Moats left end to HST 36 for no gain (G.Brackett, A.Johnson). | | |
| 2nd and 10 at HOU 36 | J.Jones right end pushed ob at HST 41 for 5 yards (A.Bethea). Handoff to S. Slaton. | | |
| 3rd and 5 at HOU 41 | (Shotgun) PENALTY on HST-C.White, False Start, 5 yards, enforced at HST 41 - No Play. | | |
| 3rd and 10 at HOU 36 | M.Schaub scrambles left guard to HST 38 for 2 yards (J.Powers). | | |
| 4th and 8 at HOU 38 | M.Turk punts 42 yards to IND 20, Center-J.Dreessen, fair catch by T.Rushing. | | |
| DRIVE TOTALS: HOU 0, IND 10, 3 plays, -5 yards, 2:16 elapsed |
| |
| Indianapolis Colts at 1:41 | HOU | IND |
| 1st and 10 at IND 20 | P.Manning pass incomplete short right to C.Simpson (B.Cushing). | | |
| 2nd and 10 at IND 20 | (Shotgun) P.Manning pass short left to R.Wayne pushed ob at IND 35 for 15 yards (Du.Robinson). | | |
| 1st and 10 at IND 35 | (Shotgun) P.Manning pass short middle to D.Clark to IND 41 for 6 yards (B.Cushing). | | |
| 2nd and 4 at IND 41 | P.Manning pass short left to R.Wayne to HST 48 for 11 yards (D.Ryans). | | |
| 1st and 10 at HOU 48 | P.Manning pass short right to D.Clark to HST 41 for 7 yards (B.Cushing, J.Reeves). | | |
| End of Period | | |
| DRIVE TOTALS: HOU 0, IND 10, 10 plays, 61 yards, 3:51 elapsed |
Houston 17, 
Indianapolis 20