| 1st Quarter | | SDG | NYG |
| | N.Kaeding kicks 62 yards from SD 30 to NYG 8. D.Hixon to NYG 23 for 15 yards (S.Gregory, K.Wilson). PENALTY on NYG-G.Wilkinson, Illegal Block Above the Waist, 10 yards, enforced at NYG 21. Officially, a return for 13 yards. | | |
| |
| New York Giants at 15:00 | SDG | NYG |
| 1st and 10 at NYG 11 | E.Manning pass short right to M.Manningham to NYG 27 for 16 yards (E.Weddle, S.Cooper). | | |
| 1st and 10 at NYG 27 | B.Jacobs left tackle to NYG 30 for 3 yards (S.Phillips). | | |
| 2nd and 7 at NYG 30 | B.Jacobs up the middle to NYG 45 for 15 yards (Q.Jammer). | | |
| 1st and 10 at NYG 45 | E.Manning sacked at NYG 45 for 0 yards (J.Cesaire). | | |
| 2nd and 10 at NYG 45 | B.Jacobs right end to SD 43 for 12 yards (E.Weddle). | | |
| 1st and 10 at SD 43 | A.Bradshaw left tackle to SD 38 for 5 yards (K.Ellison). | | |
| 2nd and 5 at SD 38 | E.Manning pass short left to B.Jacobs to SD 37 for 1 yard (K.Ellison, B.Siler). | | |
| 3rd and 4 at SD 37 | (Shotgun) E.Manning pass short right to S.Smith to SD 30 for 7 yards (S.Gregory). | | |
| 1st and 10 at SD 30 | E.Manning pass short right to S.Smith to SD 22 for 8 yards (K.Ellison). Penalty on SD-O.Nwagbuo, Defensive Offside, declined. | | |
| 2nd and 2 at SD 22 | B.Jacobs left tackle to SD 21 for 1 yard (S.Cooper, E.Weddle). | | |
| 3rd and 1 at SD 21 | A.Bradshaw left guard to SD 21 for no gain (K.Ellison, S.Phillips). | | |
| 4th and 1 at SD 21 | (Field Goal formation) J.Feagles up the middle to SD 29 for -8 yards (S.Phillips). FUMBLES (S.Phillips), RECOVERED by SD-S.Merriman at SD 29. S.Merriman to SD 29 for no gain (J.Feagles). | | |
| DRIVE TOTALS: SD 0, NYG 0, 11 plays, 73 yards, 7:23 elapsed |
| |
| San Diego Chargers at 7:37 | SDG | NYG |
| 1st and 10 at SD 29 | P.Rivers pass short right to L.Naanee to SD 35 for 6 yards (M.Boley, B.Johnson). | | |
| 2nd and 4 at SD 35 | P.Rivers pass short left to V.Jackson to SD 40 for 5 yards (C.Webster). | | |
| 1st and 10 at SD 40 | L.Tomlinson up the middle to SD 42 for 2 yards (O.Umenyiora). | | |
| 2nd and 8 at SD 42 | P.Rivers pass short right to A.Gates to SD 42 for no gain (T.Thomas, F.Robbins). Penalty on SD-S.Mruczkowski, Ineligible Downfield Pass, declined. | | |
| 3rd and 8 at SD 42 | (Shotgun) P.Rivers pass incomplete deep right to M.Floyd (B.Johnson). | | |
| 4th and 8 at SD 42 | M.Scifres punts 40 yards to NYG 18, Center-D.Binn, fair catch by D.Hixon. | | |
| DRIVE TOTALS: SD 0, NYG 0, 5 plays, 13 yards, 2:24 elapsed |
| |
| New York Giants at 5:13 | SDG | NYG |
| 1st and 10 at NYG 18 | (Shotgun) E.Manning pass short middle to S.Smith to NYG 21 for 3 yards (B.Siler). | | |
| 2nd and 7 at NYG 21 | B.Jacobs left guard to NYG 23 for 2 yards (S.Cooper, K.Ellison). | | |
| 3rd and 5 at NYG 23 | (Shotgun) PENALTY on NYG-E.Manning, Delay of Game, 5 yards, enforced at NYG 23 - No Play. | | |
| 3rd and 10 at NYG 18 | (Shotgun) E.Manning pass incomplete deep right to H.Nicks (K.Ellison). | | |
| 4th and 10 at NYG 18 | (Punt formation) PENALTY on NYG-K.Dockery, False Start, 5 yards, enforced at NYG 18 - No Play. | | |
| 4th and 15 at NYG 13 | J.Feagles punts 32 yards to NYG 45, Center-Z.DeOssie, out of bounds. | | |
| DRIVE TOTALS: SD 0, NYG 0, 3 plays, -5 yards, 2:14 elapsed |
| |
| San Diego Chargers at 2:59 | SDG | NYG |
| 1st and 10 at NYG 45 | L.Tomlinson right tackle to NYG 45 for no gain (J.Tuck, M.Johnson). | | |
| 2nd and 10 at NYG 45 | P.Rivers pass short left to V.Jackson to NYG 29 for 16 yards (C.Webster). | | |
| 1st and 10 at NYG 29 | P.Rivers pass incomplete deep left to K.Wilson [A.Pierce]. | | |
| 2nd and 10 at NYG 29 | P.Rivers pass short right to L.Tomlinson to NYG 29 for no gain (D.Clark, C.Webster). | | |
| 3rd and 10 at NYG 29 | (Shotgun) P.Rivers pass short middle to A.Gates to NYG 10 for 19 yards (B.Johnson) [O.Umenyiora]. | | |
| End of Period | | |
| DRIVE TOTALS: SD 0, NYG 0, 6 plays, 45 yards, 3:04 elapsed |
San Diego 21, 
NY Giants 20