The rookie starter appeared to hurt his left foot in Saturday's 20-3 victory over Baltimore.
If he cannot play, coach Jim Caldwell has said rookie Jacob Lacey would start in his place.
Lacey started nine games this season, is fifth on the team in tackles with 78, has three interceptions and returned one for a touchdown.
Starting safety Antoine Bethea made it through the entire practice Friday and is probable with a bruised back. Offensive lineman Tony Ugoh was the only other player to sit out Friday, although the team said Ugoh was resting.