Keiaho, who played with a dislocated right elbow last week against New Orleans, made seven tackles and had an interception against the Saints. Tyjuan Hagler made his first NFL start in Keiaho's place. Hagler appeared in nine games in 2006, playing mostly special teams.
Morris had been listed as questionable with a rib injury. Former Titans linebacker Rocky Boiman started in his place.
Being short-handed at linebacker could hurt against the Titans, who boast one of the best rushing attacks in the league.
The Titans combined for 433 rushing yards last season against the Colts and are coming off a 282-yard performance in a season-opening win against the Jacksonville Jaguars.
The Titans deactivated defensive end Bryce Fisher, who was acquired in a trade with the Seattle Seahawks on Tuesday. Tennessee also deactivated defensive tackle Randy Starks, who did not play for the first time since his rookie season in 2004. Starks' absence leaves open more playing time for Corey Simon, a former Colts lineman who was picked up Aug. 28.
This game is a battle for early control of the AFC South. The Indianapolis defense came up big last week against the Saints, but will the Colts be able to do it again versus a stout Tennessee offensive line that dominated Jacksonville last week? Tennessee also came up with a great defensive performance last week, but how will the Jaguars deal with the versatile Colts? These teams split two games last season and both ran the ball effectively. Titans QB Vince Young will once again be in a high-pressure situation this season and it will be interesting to see how he handles it.