Henry, the Broncos' leading rusher, has missed three of the Broncos' past four games. He also sat out Denver's overtime loss to Green Bay on Oct. 29 with sore ribs.
Henry is fighting to keep the league from suspending him over the results of a drug test. He had a hearing with the NFL on Friday in Phoenix and could hear back from the league as soon as Tuesday.
If he's unsuccessful, Henry faces a yearlong suspension.
Selvin Young replaced Henry in the backfield. Young had 109 yards and a touchdown last Sunday against Kansas City.
The Broncos didn't activate receiver Javon Walker, who's recovering from surgery on his right knee.
Tennessee also waived linebacker LeVar Woods before the game.
More from ESPN.com
Loose sod at 49ers' new stadium removed The San Francisco 49ers were working to re-sod the field at new Levi's Stadium on Thursday, a day after a public workout was cut short and moved to the regular practice fields because players were slipping.
Titans take Ice Bucket Challenge for Shaw Standing on twitching legs he pointed out, former Tennessee Titans linebacker Tim Shaw watched his former team take the Ice Bucket Challenge, shaking hands with or hugging many of them after the show of support.
This is a bigger game than it might look because both of these teams are surprisingly in the playoff hunt despite flaws, but neither can afford many more slips. The Titans are coming off a physical loss to Jacksonville (probably their wild-card playoff rival) and Denver is actually in the hunt to win the mediocre AFC West with a win over Kansas City in Week 10. The Broncos are coming off a long-awaited good defensive performance over a mediocre Chiefs offense, but it's something to build on, while the Titans couldn't stop the power run game and ball control style of the Jaguars.
Can an up and down Vince Young make plays versus this temporarily improved Broncos' defense, and also establish a run game versus an overload run defense? And can Jay Cutler attack a good Tennessee defense without the promise of a stable run game? This will be physical and it will be interesting to watch how these young quarterbacks handle a national stage.