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SEATTLE (AP) -- The Seattle Seahawks know Trent Dilfer has a sprained right knee. They just don't know how serious the injury is to their starting quarterback.

Dilfer was injured in the second quarter of the Seahawks' 28-10 loss to the Indianapolis Colts on Saturday night.

Coach Mike Holmgren said he expected Dilfer to have an MRI test Saturday night.

"Look, he hurt his knee,'' Holmgren said. "I will be more than happy to tell you what's wrong with it tomorrow.''

Dilfer, given the starting job during the offseason, was not available to talk to the media after the game, but he issued a statement through the team.

"Whatever the outcome, I know I can handle it,'' said Dilfer, who led the Baltimore Ravens to a Super Bowl victory over the New York Giants in the 2001 Super Bowl.

Playing in his third series against the Colts, Dilfer was hit by defensive tackle James Cannida and defensive end Chad Bratzke as he attempted a pass to Koren Robinson with 2:02 gone in the second quarter.

The 6-foot-2, 305-pound Cannida was Dilfer's teammate for two seasons (1998-99) in Tampa Bay.

"My guy was lined up to my outside,'' Cannida said. "I just tried to beat him inside and get to the QB. I didn't want nothing bad to happen to him (Dilfer).''

Dilfer was helped off the field and carted to the Seahawks locker room. He threw a 20-yard touchdown pass to James Williams in the first quarter and the Seahawks led 10-0 when Dilfer left and was replaced by Matt Hasselbeck.

Indianapolis backup quarterback Brock Huard, acquired from Seattle in April for a fifth-round draft choice, passed for two touchdowns in front of a crowd of 52,902 in the inaugural game at 67,000-seat new Seahawks Stadium.

The Seahawks, who are hoping Dilfer could lead them back to the playoffs this season, tried to take their starting quarterback's injury calmly.

"Injuries happen,'' center Robbie Tobeck said. "This is the NFL and whoever we have out there, we've got to win games and everyone has to pick it up.''

Holmgren said the Seahawks might have to go out and get a veteran quarterback if Dilfer is lost for a lengthy period. Hasselbeck would be the starter for the Seahawks if Dilfer is out.

"I don't worry about Matt so much,'' he said. "But we've got to see now how No. 2 and No. 3 are if Trent is out for a while.''

Huard sparkled in a return to Seattle.

"It was pretty strange,'' said Huard, who played three seasons for the Seahawks after starring at the University of Washington. "I just had to get ready and not get caught up with everything.''

The new stadium was built at a cost of $430 million at the site of the former Kingdome in downtown Seattle across the street from the Seattle Mariners' Safeco Field.

The Colts, who fired Jim Mora and hired Tony Dungy to be their coach after going 6-10 last season, scored the final 28 points.

"We didn't get off to a great start,'' Dungy said. "But I think some of our guys learned a lesson about life in the NFL. You have to hang in there and keep digging.''

After Aaron Elling gave Seattle a 10-0 lead with a 38-yard field goal with three minutes left in the opening period, the Colts started their comeback after Huard replaced starter Peyton Manning.

The Colts cut the Seahawks' lead to 10-7 at halftime on Huard's scoring pass to Walters in the final minute in the opening half. They went ahead 14-10 on Huard's touchdown pass to Haddad at 11:35 of the third quarter.

Indianapolis added its third touchdown 63 seconds later on a 1-yard run by Jim Finn after rookie defensive end Josh Mallard caused rookie running back Maurice Morris to fumble and linebacker Sam Sword recovered the ball at the Seattle 31.

The Colts added a touchdown with 40 seconds left on an 85-yard interception return by defensive back Clifton Crosby. He picked off a pass by rookie Jeff Kelly and returned it up the right sideline in front of Holmgren and the Seahawks.

Dilfer completed nine of 11 passes for 94 yards and a touchdown, without an interception, while Manning was 5-for-11 for 46 yards, with no interceptions in two series.

Huard was 12-for-16 for 161 yards, with two touchdowns and no interceptions, while Hasselbeck was 14-for-22 for 139 yards, with no interceptions.

"Trent means a lot to this team,'' Hasselbeck said. "There was a little bit of an emotional letdown tonight and maybe some focus was lost. That can't happen.''