FOXBOROUGH, Mass. -- Tom Brady screamed. The fans went quiet.
The seemingly indestructible star of the New England Patriots lay on the ground, clutching his left knee. The NFL's reigning MVP and three-time Super Bowl champion was done for the day -- at least.
"He was in a lot of pain. When you hear a scream, you know that," Kansas City safety Bernard Pollard said after hitting Brady on the left leg midway through the first quarter.
Untested Matt Cassel took over, and played well as the Patriots beat the Chiefs 17-10 in Sunday's opener. But they needed a last minute defensive stand to do it.
There was no word on the extent of Brady's injury -- "I am not sure what we are dealing with," coach Bill Belichick said -- or how long he would be out. But his 128-game starting streak, third-longest in NFL history, is in jeopardy.
Various reports Sunday night said Belichick told the players that the injury was serious. The Patriots were already looking for a possible replacement for Brady. A person familiar with the situation told The Associated Press that former Tampa Bay quarterback Chris Simms was coming in Monday for a physical.
"It kind of looked bad," Randy Moss said. "I know the show must go on and, hopefully, Matt Cassel is ready to step in."
He was Sunday. That came as somewhat of a surprise after he failed to produce a touchdown in 17 exhibition series, leading many to wonder if he would even make the team on which he backed up Brady the past three seasons.
"He did a good job coming in and, obviously, made some big plays for us," tackle Matt Light said. "That guy's had a lot of criticism cast down on him and I felt like he stepped up and played like a professional."
Still, the Patriots plummeted from an exclamation point of an unbeaten 2007 regular season to a huge question mark in 2008. They lost the Super Bowl to the New York Giants 17-14 then went 0-4 in the exhibition season while Brady had a right foot injury and missed all four games.
But for the first time in 57 games, Brady wasn't listed on the Patriots' injury report for Sunday's game. He completed seven of 11 passes for 76 yards.
Cassel, who had thrown just 39 passes in his first three seasons, went 13-for-18 for 152 yards and one touchdown.
"This is something I've been preparing for [for] a long time. It's not something that we expected to come up on opening day," he said. "Since I've been here and been around Tom, he's always popped back up."
Not this time. And Kansas City also had its own quarterback woes.
Damon Huard, playing after Brodie Croyle left with a bruised shoulder late in the third quarter, completed a 68-yard pass to Devard Darling, who cornerback Deltha O'Neal ran down and tackled at the Patriots 5 with 53 seconds left.
"It was a gut check. Go get him," said O'Neal, a two-time Pro Bowler who signed early last week. "That's what my whole mentality was."
"Matt played well," Huard said. "At the end of the day, it's how quarterbacks are measured."
But, Chiefs cornerback Patrick Surtain said, "Brady is Brady. There's only one of him."
Last season, Brady set an NFL record with 50 touchdown passes, but it ended in disappointment with the Super Bowl loss.
They stayed calm without him Sunday.
"Worry about the consequences later," linebacker Tedy Bruschi said. "Whoever's in there, do your job."
With the game scoreless, Brady was hurt when Pollard hit him low as he heaved a 28-yard completion to Moss. But Moss fumbled the ball away.
Cassel was impressive on his first possession, starting at his 2. With a third down at the 1, he threw a 51-yard completion to Moss.
"We had them deep into their territory," defensive tackle Glenn Dorsey said, "but they made a good play."
Eight plays later, Cassel and Moss hooked up for a 10-yard touchdown and a 7-0 lead.
It was Moss' 126th touchdown, tying Jim Brown for eighth most overall, and 125th on a reception, tying him for fourth in NFL history.
The Chiefs cut the lead to 7-3 on a 40-yard field goal by Nick Novak with 17 seconds left in the half.
Cassel led another impressive drive, covering 80 yards in which he completed all four passes. Sammy Morris ended it with a 5-yard scoring run for a 14-3 lead.
The injury marred the Patriots season opener for the second straight year.
They won 38-14 at the Jets in last year's first game, then were punished by the NFL after an employee was caught filming the Jets' defensive signals. Belichick was fined $500,000; the team was fined $250,000, and the Patriots also lost a first-round draft choice.
"For Week 1, you never know what to expect," Light said, "and this was one of those weeks."
A new banner hung from under the third deck marking their 16-0 regular-season record last year. ... Croyle, now 0-7 as a starter, went 11-for-19 for 88 yards. ... The Patriots improved their NFL best regular-season winning streak to 20 games.
For the second time this season, Texans coach Bill O'Brien is considering an in-season quarterback change.
Receiver Andre Johnson picked the perfect time to catch his first touchdown as a member of the Indianapolis Colts.
Texans running back Arian Foster was taken to the locker room in the second quarter of Thursday night's 27-20 loss to the Colts with an unspecified injury.
The Miami Dolphins fired defensive coordinator Kevin Coyle on Thursday after four seasons with the team and promoted defensive backs coach Lou Anarumo to take his place.
Jay Cutler said on Thursday he's not 100 percent but is pushing through his hamstring discomfort in light of all the injuries the Bears have suffered this year.
Dallas Cowboys coach Jason Garrett spoke with defensive end Greg Hardy regarding his comments about returning "guns blazing," and about the wife of New England Patriots quarterback Tom Brady.