EAST RUTHERFORD, N.J. -- Steve Spagnuolo jogged out to midfield shortly after the final gun, shook hands with mentor Tom Coughlin and probably wished him well the rest of the season.
Eli Manning threw two touchdown passes and linebacker Michael Boley scored on a 65-yard fumble return to lead New York to a 28-16 victory over the Rams in the first matchup between Coughlin and the former defensive coordinator who helped the Giants win the Super Bowl over Tom Brady and the New England Patriots in February 2008.
"It seemed when they gave us a little opening, we jumped in there and got points and scored touchdowns and didn't settle for field goals," said Manning, who completed 18 of 29 passes for 200 yards with one interception.
This one was ugly with mistakes by the Rams (0-2) giving New York (1-1) a crucial win after a disappointing loss to Washington in the season opener.
"It's a little bit of the same story as last week, we shot ourselves in the foot," said Spagnuolo, who kept the media waiting 25 minutes after the game before talking. "It's difficult enough to beat any football team in this league without doing that, when you kind of beat yourself."
All four of New York's touchdowns resulted directly from St. Louis mistakes.
Manning hit Hakeem Nicks with a 3-yard TD pass after a muffed punt and Domenik Hixon made a spectacular juggling grab on a 22-yard score after a busted coverage late in the first half. Boley's touchdown came on the lateral and New York's final score was set up by a third-down pass interference call early in the second half.
Sam Bradford threw a touchdown pass and Josh Brown kicked three short field goals for the Rams, who moved up and down the field, gaining 367 yards. The one area they could not move was in the red zone.
"The thing I liked about what we did tonight was we showed resiliency," said Giants Pro Bowl defensive end Justin Tuck, who had 1½ sacks in his first game of the season after sitting out the opener with a neck injury. "In a lot of those situations, if they get touchdowns, that score is a lot different."
Bradford, who was 22 of 46 for 331 yards, might have made the biggest mistakes, throwing a pass backward and seeing Boley run it into the end zone.
It was that kind of night for the Rams.
The Rams killed themselves in the red zone. They settled for three short field goals after drives stalled inside the Giants 10, with the first coming after they got a first-and-goal at the 1 following a 68-yard catch and run by Danario Alexander, who had three catches for 122 yards.
New York built a 21-6 halftime lead and was never threatened again.
After Manning threw an interception deep in Rams territory on the opening drive, the Giants looked lost for a couple of minutes, until the Rams woke them up with their first big mistake.
It resulted because St. Louis was without regular punt returner Danny Amendola.
Nicks, who was questionable for the game with a bruised knee, put New York ahead with the 3-yard TD catch. The score came after New York got a first down at the Rams' 9 after Bradley Fletcher was called for pass interference against Nicks.
A 25-yard field goal by Brown closed the gap to 7-6 later in the quarter, and the Rams seemed to be in position to take the lead early in the second quarter when Bradford moved them to the Giants 27.
However on third-and-8, Bradford tried to throw a halfback screen to Williams who was lined up as a receiver. The pass was thrown backward, making it a lateral and Boley picked up the fumble and ran 65 yards for the touchdown that made it 14-6.
"It was a big momentum lift," Boley said after his first career regular-season NFL touchdown. "Anytime the defense scores, it's a bonus. Not only does the defense feed off it but it gives the offense some momentum as well. It looked like he just dropped it. It was a pretty good throw. He just missed it. Scoop and score. We work on that drill a couple of times each week. It paid off."
Hixon made a one-handed catch of Manning's pass -- juggling the ball three times with his right hand -- for a 22-yard touchdown. He hurt his calf on the play and barely played in the second half. He missed all of last season after tearing the ACL in his right knee in June.
"It happened so fast, I don't know if it him in arm or hit me in the shoulder," Hixon said. "Until I see the replay, I won't be able to tell you. At the end of the day we always say, catch the ball. I didn't want to get fined by the receivers for not catching it."
A 17-yard pass interference penalty against Justin King kept the Giants' opening drive in the second half alive and Jacobs scored one play after Manning got New York a first down with a 23-yard screen pass to Ahmad Bradshaw.
Bradford closed the scoring with a 19-yard touchdown pass to Alexander late in the third quarter.
This was the Rams' first appearance on Monday Night Football since Dec. 11, 2006. ... Coughlin benched veteran cornerback Aaron Ross in the second half and played Michael Coe. A first-round draft pick in 2007, Ross moved into the starting lineup when Terrell Thomas was lost for the season with a knee injury. ... Manningham did not play in the second half because of a concussion. ... The Giants rushed for 119 yards and limited the Rams to 67 ... St. Louis starting RB Steven Jackson was not active because of a quad injury. ... NFL teams have scored a record 1,502 points in the first two weeks of the season, breaking the old mark of 1,442 set in 2002.
The Redskins are planning on starting Kirk Cousins at quarterback in their regular-season opener against the Dolphins, sources told ESPN's Dianna Russini.
The Redskins and Pro Bowl left tackle Trent Williams have agreed on a five-year, $66 million extension, his agent told ESPN.
After further tests, Robert Griffin III has not been cleared to play Saturday night against the Ravens, casting doubt into his availability for the Redskins' season opener.
Jets center Nick Mangold threw his most memorable block of the summer at his home in New Jersey, stopping burglars from breaking into his car and helping end a crime spree in his neighborhood.
Russell Wilson clarified Thursday that he didn't suffer a concussion in the NFC title game, expanding on comments about how he believes recovery water helped him last postseason.
Seahawks defensive end Michael Bennett has been fined $17,363 for striking Chiefs quarterback Alex Smith in the head and neck area during last week's preseason game, a league source confirmed.