Offensive Leaders
| PASSER RATING | RAT | |
Peyton Manning | 1. Peyton Manning, IND | 104.1 |
| 2. Carson Palmer, CIN | 101.1 | |
| 3. Ben Roethlisberger, PIT | 98.6 | |
| 4. Matt Hasselbeck, SEA | 98.2 | |
| 5. Marc Bulger, STL | 94.4 | |
| Complete Leaders | ||
| RUSHING YARDS | YDS | |
Shaun Alexander | 1. Shaun Alexander, SEA | 1880 |
| 2. Tiki Barber, NYG | 1860 | |
| 3. Larry Johnson, KC | 1750 | |
| 4. Clinton Portis, WSH | 1516 | |
| 5. Edgerrin James, IND | 1506 | |
| Complete Leaders | ||
| RECEIVING YARDS | YDS | |
Steve Smith | 1. Steve Smith, CAR | 1563 |
| 2. Santana Moss, WSH | 1483 | |
| 3. Chad Johnson, CIN | 1432 | |
| 4. Larry Fitzgerald, ARI | 1409 | |
| 5. Anquan Boldin, ARI | 1402 | |
| Complete Leaders | ||
Defensive Leaders
| TACKLES | TACK | |
Jonathan Vilma | 1. Jonathan Vilma, NYJ | 169 |
| 2. Zach Thomas, MIA | 158 | |
| 3. London Fletcher, BUF | 157 | |
| 4. Donnie Edwards, SD | 152 | |
| 5. Andra Davis, CLE | 149 | |
| Complete Leaders | ||
| SACKS | SACK | |
Derrick Burgess | 1. Derrick Burgess, OAK | 16.0 |
| 2. Osi Umenyiora, NYG | 14.5 | |
| 3. Simeon Rice, TB | 14.0 | |
| 4. Kyle Vanden Bosch, TEN | 12.5 | |
| 5. Jason Taylor, MIA | 12.0 | |
| Complete Leaders | ||
| INTERCEPTIONS | INT | |
Ty Law | 1. Ty Law, NYJ | 10 |
| 1. Deltha O'Neal, CIN | 10 | |
| 3. Darren Sharper, MIN | 9 | |
| 4. Nathan Vasher, CHI | 8 | |
| 4. Champ Bailey, DEN | 8 | |
| Complete Leaders | ||
Data provided by Elias Sports Bureau
