| Team Transactions |
| DATE | TRANSACTION |
| November 12, 2009 | Placed G Mike Goff on injured reserve. Signed LB Justin Rogers. |
| November 10, 2009 | Released RB Larry Johnson. |
| November 8, 2009 | Activated RB Kolby Smith off the physically-unable-to-perform list. Released WR Bobby Engram. |
| November 4, 2009 | Placed S Jarrad Page on injured reserve. Signed CB Travis Daniels. |
| November 4, 2009 | Claimed WR Chris Chambers off waivers from San Diego. |
| October 29, 2009 | Suspended RB Larry Johnson for one game for conduct detrimental to the club. |
| October 26, 2009 | Signed WR Lance Long from the practice squad. Released WR Quinten Lawrence. |
| October 22, 2009 | Signed DT Kenny Smith. Signed DT Marlon Favorite to the practice squad. |
| October 18, 2009 | Activated T Barry Richardson from the practice squad. Waived LB Justin Rogers. |
| October 1, 2009 | Signed LB David Herron and CB Mike Richardson. |
| September 30, 2009 | Traded QB Tyler Thigpen to Miami for an undisclosed draft pick. |
| September 17, 2009 | Signed WR Lance Long to the practice squad. Released WR Rodney Wright from the practice squad. |
| September 8, 2009 | OT Barry Richardson added to practice squad |
| September 7, 2009 | CB Jackie Bates added to practice squad; TE Tom Crabtree added to practice squad; DT Dion Gales added to practice squad; DT Bobby Greenwood added to practice squad; G Darryl Harris added to practice squad; RB Javarris Williams added to practice squad; WR Rodney Wright added to practice squad |
| September 6, 2009 | OT Barry Richardson cut; G Ryan O'Callaghan acquired from waivers |
| September 5, 2009 | CB Jackie Bates cut; TE Tom Crabtree cut; DT Dion Gales cut; DT Bobby Greenwood cut; G Darryl Harris cut; WR Taurus Johnson cut; DT Derek Lokey cut; S Bernard Pollard cut; CB Ricky Price cut; RB Javarris Williams cut; WR Rodney Wright cut; G Ryan O'Callaghan cut; WR Ashley Lelie cut; LB Zach Thomas cut |
| September 4, 2009 | FB Jed Collins cut; CB Londen Fryar cut; LB Corey Smith cut; OT Herb Taylor cut; G Tavares Washington cut; CB Travis Daniels cut; C Eric Ghiaciuc cut; OT Damion McIntosh cut |
| September 1, 2009 | OT Cameron Goldberg cut; DE Alfonso Boone cut; WR Amani Toomer cut; RB Kolby Smith placed on PUP list; WR D'Juan Woods placed on PUP list; RB Andre Brown placed on PUP list; CB Stoney Woodson placed on PUP list; LB Stewart Bradley placed on PUP list; TE Cornelius Ingram placed on PUP list; WR Brooks Foster placed on PUP list; WR Demetrius Byrd placed on PUP list; CB Brandon Hughes placed on PUP list |
| August 24, 2009 | Waived linebacker Vince Redd; acquired offensive linemen Andy Alleman and Ikechuku Ndukwe from the Miami Dolphins for an undisclosed selection in the 2010 NFL Draft; waived center Brian De La Puente. |
| August 18, 2009 | Signed wide receiver Ashley Lelie. |
| August 13, 2009 | Signed long snapper Thomas Gafford. |
| August 8, 2009 | Signed defensive end Tyson Jackson. |
| August 8, 2009 | Claimed quarterback Matt Gutierrez off waviers. |
| August 5, 2009 | Waived quarterback Ingle Martin. |
| August 4, 2009 | Signed wide receiver Amani Toomer. |
| July 30, 2009 | Signed defensive end Alex Magee, cornerback Donald Washington and wide receiver Quinten Lawrence. |
| July 29, 2009 | Waived kicker Connor Barth. |
| July 24, 2009 | Signed running back Javarris Williams. |
| July 14, 2009 | Signed quarterback Matt Cassel to a multi-year contract extension. |
| July 1, 2009 | Signed offensive tackle Colin Brown. |
| June 26, 2009 | Signed tight end Jake O'Connell. |
| June 26, 2009 | Signed safety Mike Brown. |
| June 24, 2009 | Signed kicker Ryan Succop. |
| June 21, 2009 | Waived long snapper Thomas Gafford, wide receiver C.J. Jones, defensive tackle T.J. Jackson and linebcker Darrell Robertson. |
| May 29, 2009 | Released running back J.J. Arrington. |
| May 28, 2009 | Waived defensive end Brian Johnston. |
| May 22, 2009 | Named Mark Donovan executive vice president and chief operating officer. |
| May 15, 2009 | Traded tight end Tony Gonzalez to the Atlanta Falcons for a 2010 second-round pick. |
| May 10, 2009 | Signed cornerbacks Jackie Bates and Londen Fryar, linebackers Jovan Belcher, Corey Smith and Pierre Walters, tight end Tom Crabtree, defensive ends Dion Gales and Robert Greenwood, offensive tackle Cameron Goldberg, guard Darryl Harris, wide receiver Taurus Johnson and safety Ricky Price; named Denny Thum president. |
| May 2, 2009 | Named Phil Emery director of college scouting, Jim Nagy regional scout, Jay Muraco and Pat Sperduto area scouts; promoted Rod Perry to area scout. |
| April 30, 2009 | Signed free agent center Eric Ghiaciuc. |
| April 25, 2009 | Signed tight end Tony Curtis. |
| April 24, 2009 | Traded tight end Tony Gonzalez to the Atlanta Falcons for a 2010 second-round pick. |
| April 21, 2009 | Signed tight end Sean Ryan. |
| April 13, 2009 | Signed linebacker Zach Thomas. |
| March 19, 2009 | Released long snapper Jean-Philippe Darche. |
| March 18, 2009 | Released cornerback David Macklin. |
| March 17, 2009 | Agreed to terms with wide receivers Bobby Engram, Terrance Copper and linebacker Monty Beisel. |
| March 11, 2009 | Released quarterback Quinn Gray. |
| March 10, 2009 | Agreed to terms with cornerback Travis Daniels. |
| March 6, 2009 | Agreed to terms with safety Jon McGraw and linebacker Darrell Robertson. |
| March 5, 2009 | Agreed to terms with wide receiver C.J. Jones. |
| March 3, 2009 | Named Ronnie Bradford defensive assistant coach and Nick Sirianni offensive quality control coach. |
| February 28, 2009 | Acquired quarterback Matt Cassel and linebacker Mike Vrabel from the New England Patriots for a 2009 second-round pick. |
| February 25, 2009 | Released quarterback Damon Huard, cornerback Patrick Surtain, linebacker Donnie Edwards and tight end Michael Merritt. |
| February 19, 2009 | Named Maurice Carthon assistant coach. |
| February 14, 2009 | Fired tight ends coach Jon Embree, defensive assistant Michael Ketchum, running backs coach Curtis Modkins, offensive assistant Kevin Patullo and wide receivers coach Eric Price. |
| February 6, 2009 | Named Todd Haley coach. |
| January 23, 2009 | Fired coach Herman Edwards. |
| January 13, 2009 | Named Scott Pioli general manager. |
| January 12, 2009 | Agreed to terms with quarterback Ingle Martin to a two-year contract. |
| January 8, 2009 | Signed fullback Jed Collins. |