| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matthew Stafford |
1. Matthew Stafford, QB | DET | W 38-37 vs. CLE | 26 | 43 | 422 | 5 | 2 | 1 | 0 | 112.7 |
| 2. Ben Roethlisberger, QB | PIT | L 27-24 at KAN | 32 | 42 | 398 | 3 | 2 | 3 | 0 | 109.0 | |
| 3. Eli Manning, QB | NYG | W 34-31 vs. ATL | 25 | 39 | 384 | 3 | 1 | 1 | 0 | 111.5 | |
| 4. Aaron Rodgers, QB | GNB | W 30-24 vs. SFO | 32 | 45 | 344 | 2 | 0 | 2 | 0 | 108.0 | |
| 5. Tom Brady, QB | NWE | W 31-14 vs. NYJ | 28 | 41 | 310 | 1 | 0 | 2 | 0 | 98.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Chris Johnson |
1. Chris Johnson, RB | TEN | W 20-17 at HOU | 29 | 151 | 5.2 | 0 | 36 | 0 | |
| 2. Ryan Grant, RB | GNB | W 30-24 vs. SFO | 21 | 129 | 6.1 | 1 | 26 | 0 | ||
| 3. DeAngelo Williams, RB | CAR | L 24-17 vs. MIA | 13 | 122 | 9.4 | 0 | 50 | 0 | ||
| 4. Bernard Scott, RB | CIN | L 20-17 at OAK | 21 | 119 | 5.7 | 0 | 61 | 0 | ||
| 5. Ricky Williams, RB | MIA | W 24-17 at CAR | 22 | 119 | 5.4 | 2 | 46 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Terrell Owens |
1. Terrell Owens, WR | BUF | L 18-15 at JAC | 9 | 197 | 21.9 | 1 | 98 | 0 | |
| 2. Wes Welker, WR | NWE | W 31-14 vs. NYJ | 15 | 192 | 12.8 | 0 | 43 | 0 | ||
| 3. Calvin Johnson, WR | DET | W 38-37 vs. CLE | 7 | 161 | 23.0 | 1 | 75 | 0 | ||
| 4. Derrick Mason, WR | BAL | L 17-15 vs. IND | 9 | 142 | 15.8 | 0 | 45 | 0 | ||
| 5. Hines Ward, WR | PIT | L 27-24 at KAN | 10 | 128 | 12.8 | 1 | 33 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
James Laurinaitis |
1. James Laurinaitis, LB | STL | L 21-13 vs. ARI | 16 | 0 | 16 | 0.0 | 0 | 0 | 0 |
| 2. David Hawthorne, LB | SEA | L 35-9 at MIN | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. David Harris, LB | NYJ | L 31-14 at NWE | 11 | 3 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Michael Boley, LB | NYG | W 34-31 vs. ATL | 11 | 2 | 13 | 1.0 | 0 | 0 | 0 | |
| 5. London Fletcher, LB | WAS | L 7-6 at DAL | 8 | 5 | 13 | 0.0 | 1 | 1 | 0 | |