| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Marc Bulger |
1. Marc Bulger, QB | STL | L 29-23 vs. CAR | 27 | 46 | 332 | 0 | 3 | 2 | 0 | 53.9 |
| 2. Peyton Manning, QB | IND | W 38-31 at KC | 22 | 30 | 304 | 3 | 0 | 1 | 0 | 138.7 | |
| 3. Jake Delhomme, QB | CAR | W 29-23 at STL | 16 | 26 | 290 | 1 | 1 | 3 | 0 | 96.6 | |
| 4. Donovan McNabb, QB | PHI | W 20-17 vs. GB | 21 | 39 | 248 | 2 | 0 | 8 | 1 | 90.5 | |
| 5. Trent Green, QB | KC | L 38-31 vs. IND | 18 | 30 | 212 | 1 | 0 | 0 | 0 | 92.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Priest Holmes |
1. Priest Holmes, RB | KC | L 38-31 vs. IND | 24 | 176 | 7.3 | 2 | 48 | 1 | |
| 2. Ahman Green, RB | GB | L 20-17 at PHI | 25 | 156 | 6.2 | 0 | 33 | 0 | ||
| 3. Edgerrin James, RB | IND | W 38-31 at KC | 26 | 125 | 4.8 | 2 | 18 | 0 | ||
| 4. Donovan McNabb, QB | PHI | W 20-17 vs. GB | 11 | 107 | 9.7 | 0 | 41 | 1 | ||
| 5. DeShaun Foster, RB | CAR | W 29-23 at STL | 21 | 95 | 4.5 | 0 | 17 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Steve Smith |
1. Steve Smith, WR | CAR | W 29-23 at STL | 6 | 163 | 27.2 | 1 | 69 | 0 | |
| 2. Isaac Bruce, WR | STL | L 29-23 vs. CAR | 7 | 116 | 16.6 | 0 | 26 | 0 | ||
| 3. Marvin Harrison, WR | IND | W 38-31 at KC | 6 | 98 | 16.3 | 0 | 38 | 0 | ||
| 4. Todd Pinkston, WR | PHI | W 20-17 vs. GB | 7 | 95 | 13.6 | 1 | 45 | 0 | ||
| 5. Derrick Mason, WR | TEN | L 17-14 at NE | 7 | 90 | 12.9 | 1 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Peter Sirmon |
1. Peter Sirmon, LB | TEN | L 17-14 at NE | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 |
| 2. Keith Bulluck, LB | TEN | L 17-14 at NE | 9 | 2 | 11 | 0.0 | 0 | 0 | 0 | |
| 3. David Thornton, LB | IND | W 38-31 at KC | 9 | 2 | 11 | 0.0 | 0 | 0 | 0 | |
| 4. Shawn Barber, LB | KC | L 38-31 vs. IND | 10 | 0 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Travis Fisher, CB | STL | L 29-23 vs. CAR | 8 | 1 | 9 | 0.0 | 0 | 0 | 0 | |
