| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Peyton Manning |
1. Peyton Manning, QB | IND | W 34-31 vs. SD | 27 | 44 | 383 | 2 | 1 | 4 | 0 | 95.2 |
| 2. Brett Favre, QB | GB | W 34-31 at MIN | 30 | 43 | 365 | 3 | 1 | 1 | 0 | 109.2 | |
| 3. Trent Green, QB | KC | W 31-30 vs. OAK | 32 | 45 | 358 | 2 | 1 | 4 | 1 | 100.0 | |
| 4. Brian Griese, QB | TB | L 37-20 vs. CAR | 30 | 41 | 321 | 3 | 2 | 2 | 1 | 99.7 | |
| 5. Jake Plummer, QB | DEN | W 37-16 at TEN | 21 | 26 | 303 | 2 | 1 | 0 | 0 | 124.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Domanick Williams |
1. Domanick Williams, RB | HOU | W 21-0 at JAC | 31 | 158 | 5.1 | 1 | 44 | 0 | |
| 2. Shaun Alexander, RB | SEA | W 24-21 vs. ARI | 30 | 154 | 5.1 | 3 | 23 | 0 | ||
| 3. Steven Jackson, RB | STL | W 20-7 vs. PHI | 24 | 148 | 6.2 | 1 | 43 | 0 | ||
| 4. Lee Suggs, RB | CLE | L 10-7 at MIA | 38 | 143 | 3.8 | 0 | 13 | 1 | ||
| 5. Deuce McAllister, RB | NO | W 26-13 vs. ATL | 29 | 128 | 4.4 | 0 | 25 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Donald Driver |
1. Donald Driver, WR | GB | W 34-31 at MIN | 11 | 162 | 14.7 | 1 | 34 | 0 | |
| 2. Tony Gonzalez, TE | KC | W 31-30 vs. OAK | 11 | 124 | 11.3 | 2 | 26 | 0 | ||
| 3. Brandon Stokley, WR | IND | W 34-31 vs. SD | 7 | 123 | 17.6 | 1 | 30 | 0 | ||
| 4. Muhsin Muhammad, WR | CAR | W 37-20 at TB | 8 | 115 | 14.4 | 2 | 23 | 0 | ||
| 5. Dennis Northcutt, WR | CLE | L 10-7 at MIA | 4 | 114 | 28.5 | 1 | 58 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Zach Thomas |
1. Zach Thomas, LB | MIA | W 10-7 vs. CLE | 9 | 9 | 18 | 0.0 | 0 | 0 | 0 |
| 2. Derrick Brooks, LB | TB | L 37-20 vs. CAR | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Donnie Nickey, S | TEN | L 37-16 vs. DEN | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Keith Bulluck, LB | TEN | L 37-16 vs. DEN | 7 | 7 | 14 | 0.0 | 0 | 1 | 0 | |
| 5. Ray Lewis, LB | BAL | L 20-7 at PIT | 5 | 8 | 13 | 0.0 | 0 | 0 | 0 | |
