| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matt Leinart |
1. Matt Leinart, QB | ARI | L 31-26 at MIN | 31 | 51 | 405 | 1 | 2 | 1 | 0 | 76.0 |
| 2. Drew Brees, QB | NO | W 31-13 at ATL | 21 | 30 | 349 | 2 | 0 | 2 | 0 | 131.1 | |
| 3. David Carr, QB | HOU | L 26-11 at NYJ | 39 | 54 | 323 | 1 | 1 | 4 | 0 | 85.6 | |
| 4. Tony Romo, QB | DAL | W 38-10 vs. TB | 22 | 29 | 306 | 5 | 0 | 1 | 0 | 148.9 | |
| 5. Chad Pennington, QB | NYJ | W 26-11 vs. HOU | 24 | 31 | 286 | 1 | 0 | 1 | 0 | 115.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Shaun Alexander |
1. Shaun Alexander, RB | SEA | W 34-24 vs. GB | 40 | 201 | 5.0 | 0 | 21 | 0 | |
| 2. Joseph Addai, RB | IND | W 45-21 vs. PHI | 24 | 171 | 7.1 | 4 | 15 | 0 | ||
| 3. Michael Vick, QB | ATL | L 31-13 vs. NO | 12 | 166 | 13.8 | 0 | 51 | 0 | ||
| 4. Larry Johnson, RB | KC | W 19-10 vs. DEN | 34 | 157 | 4.6 | 1 | 21 | 0 | ||
| 5. Chester Taylor, RB | MIN | W 31-26 vs. ARI | 27 | 136 | 5.0 | 1 | 28 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Larry Fitzgerald |
1. Larry Fitzgerald, WR | ARI | L 31-26 at MIN | 11 | 172 | 15.6 | 0 | 34 | 0 | |
| 2. Devery Henderson, WR | NO | W 31-13 at ATL | 4 | 158 | 39.5 | 1 | 76 | 0 | ||
| 3. Anquan Boldin, WR | ARI | L 31-26 at MIN | 9 | 140 | 15.6 | 1 | 29 | 0 | ||
| 4. Roy Williams, WR | DET | L 27-10 vs. MIA | 6 | 126 | 21.0 | 0 | 41 | 0 | ||
| 5. Chad Johnson, WR | CIN | W 30-0 at CLE | 7 | 123 | 17.6 | 0 | 43 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
D'Qwell Jackson |
1. D'Qwell Jackson, LB | CLE | L 30-0 vs. CIN | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 |
| 2. A.J. Hawk, LB | GB | L 34-24 at SEA | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. DeMeco Ryans, LB | HOU | L 26-11 at NYJ | 13 | 1 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Antoine Winfield, CB | MIN | W 31-26 vs. ARI | 13 | 0 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Randall Godfrey, LB | SD | W 21-14 vs. OAK | 12 | 1 | 13 | 1.0 | 0 | 0 | 0 | |
