| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Peyton Manning |
1. Peyton Manning, QB | IND | W 31-24 at JAC | 29 | 34 | 364 | 3 | 0 | 0 | 0 | 140.7 |
| 2. Jay Cutler, QB | DEN | L 30-23 vs. BUF | 25 | 45 | 359 | 0 | 1 | 1 | 0 | 72.4 | |
| 3. Drew Brees, QB | NO | W 42-7 at DET | 30 | 40 | 351 | 2 | 0 | 0 | 0 | 117.8 | |
| 4. Matt Cassel, QB | NE | W 47-7 vs. ARI | 20 | 36 | 345 | 3 | 0 | 1 | 0 | 116.1 | |
| 5. Ben Roethlisberger, QB | PIT | L 31-14 at TEN | 25 | 39 | 329 | 2 | 2 | 5 | 2 | 86.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Ward |
1. Derrick Ward, RB | NYG | W 34-28 vs. CAR | 15 | 215 | 14.3 | 0 | 51 | 0 | |
| 2. Cedric Benson, RB | CIN | W 14-0 at CLE | 38 | 171 | 4.5 | 0 | 46 | 1 | ||
| 3. Le'Ron McClain, FB | BAL | W 33-24 at DAL | 22 | 139 | 6.3 | 1 | 82 | 0 | ||
| 4. Maurice Morris, RB | SEA | W 13-3 vs. NYJ | 29 | 116 | 4.0 | 0 | 13 | 0 | ||
| 5. Kevin Smith, RB | DET | L 42-7 vs. NO | 24 | 111 | 4.6 | 1 | 19 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Visanthe Shiancoe |
1. Visanthe Shiancoe, TE | MIN | L 24-17 vs. ATL | 7 | 136 | 19.4 | 2 | 31 | 0 | |
| 2. Brandon Marshall, WR | DEN | L 30-23 vs. BUF | 10 | 129 | 12.9 | 0 | 24 | 1 | ||
| 3. Antonio Bryant, WR | TB | L 41-24 vs. SD | 6 | 127 | 21.2 | 1 | 71 | 1 | ||
| 4. Owen Daniels, TE | HOU | L 27-16 at OAK | 7 | 111 | 15.9 | 0 | 35 | 0 | ||
| 5. Vincent Jackson, WR | SD | W 41-24 at TB | 7 | 111 | 15.9 | 0 | 25 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
James Farrior |
1. James Farrior, LB | PIT | L 31-14 at TEN | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Jon Beason, LB | CAR | L 34-28 at NYG | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Patrick Willis, LB | SF | W 17-16 at STL | 13 | 0 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Michael Lewis, S | SF | W 17-16 at STL | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Keith Bulluck, LB | TEN | W 31-14 vs. PIT | 10 | 3 | 13 | 0.0 | 1 | 0 | 0 | |
