| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Drew Brees |
1. Drew Brees, QB | NO | L 34-32 at DEN | 39 | 48 | 421 | 1 | 0 | 1 | 0 | 110.2 |
| 2. Brian Griese, QB | TB | W 27-24 at CHI | 38 | 67 | 407 | 2 | 3 | 0 | 0 | 66.0 | |
| 3. Aaron Rodgers, QB | GB | L 27-16 vs. DAL | 22 | 39 | 290 | 0 | 0 | 5 | 0 | 80.1 | |
| 4. Eli Manning, QB | NYG | W 26-23 vs. CIN | 26 | 43 | 289 | 1 | 0 | 0 | 0 | 88.2 | |
| 5. Carson Palmer, QB | CIN | L 26-23 at NYG | 27 | 39 | 286 | 1 | 0 | 6 | 0 | 98.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Marion Barber |
1. Marion Barber, RB | DAL | W 27-16 at GB | 28 | 142 | 5.1 | 1 | 25 | 1 | |
| 2. Julius Jones, RB | SEA | W 37-13 vs. STL | 22 | 140 | 6.4 | 1 | 32 | 0 | ||
| 3. Frank Gore, RB | SF | W 31-13 vs. DET | 27 | 130 | 4.8 | 1 | 33 | 0 | ||
| 4. Larry Johnson, RB | KC | L 38-14 at ATL | 24 | 121 | 5.0 | 1 | 48 | 0 | ||
| 5. Fred Taylor, RB | JAC | W 23-21 at IND | 26 | 121 | 4.7 | 0 | 34 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Brandon Marshall |
1. Brandon Marshall, WR | DEN | W 34-32 vs. NO | 6 | 155 | 25.8 | 1 | 35 | 0 | |
| 2. T.J. Houshmandzadeh, WR | CIN | L 26-23 at NYG | 12 | 146 | 12.2 | 1 | 26 | 0 | ||
| 3. Antonio Bryant, WR | TB | W 27-24 at CHI | 10 | 138 | 13.8 | 0 | 38 | 0 | ||
| 4. Brandon Lloyd, WR | CHI | L 27-24 vs. TB | 6 | 124 | 20.7 | 1 | 27 | 0 | ||
| 5. Roddy White, WR | ATL | W 38-14 vs. KC | 5 | 119 | 23.8 | 1 | 70 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
D.J. Williams |
1. D.J. Williams, LB | DEN | W 34-32 vs. NO | 14 | 2 | 16 | 0.0 | 0 | 0 | 0 |
| 2. D'Qwell Jackson, LB | CLE | L 28-10 at BAL | 5 | 9 | 14 | 0.0 | 0 | 1 | 0 | |
| 3. Ernie Sims, LB | DET | L 31-13 at SF | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. DeMeco Ryans, LB | HOU | L 31-12 at TEN | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Antonio Pierce, LB | NYG | W 26-23 vs. CIN | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
