| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Aaron Rodgers |
1. Aaron Rodgers, QB | GB | L 30-23 at MIN | 26 | 37 | 384 | 2 | 1 | 8 | 1 | 110.6 |
| 2. Peyton Manning, QB | IND | W 34-17 vs. SEA | 31 | 41 | 353 | 2 | 1 | 0 | 0 | 107.1 | |
| 3. Ben Roethlisberger, QB | PIT | W 38-28 vs. SD | 26 | 33 | 333 | 2 | 0 | 3 | 0 | 128.9 | |
| 4. David Garrard, QB | JAC | W 37-17 vs. TEN | 27 | 37 | 323 | 3 | 0 | 2 | 1 | 126.3 | |
| 5. Matthew Stafford, QB | DET | L 48-24 at CHI | 24 | 36 | 296 | 1 | 1 | 5 | 1 | 89.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Rashard Mendenhall |
1. Rashard Mendenhall, RB | PIT | W 38-28 vs. SD | 29 | 165 | 5.7 | 2 | 32 | 0 | |
| 2. Matt Forte, RB | CHI | W 48-24 vs. DET | 12 | 121 | 10.1 | 1 | 61 | 0 | ||
| 3. Jerome Harrison, RB | CLE | L 23-20 vs. CIN | 29 | 121 | 4.2 | 0 | 21 | 1 | ||
| 4. Ronnie Brown, RB | MIA | W 38-10 vs. BUF | 20 | 115 | 5.8 | 2 | 38 | 0 | ||
| 5. Ray Rice, RB | BAL | L 27-21 at NE | 11 | 103 | 9.4 | 0 | 50 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Mohamed Massaquoi |
1. Mohamed Massaquoi, WR | CLE | L 23-20 vs. CIN | 8 | 148 | 18.5 | 0 | 30 | 0 | |
| 2. Steve Smith, WR | NYG | W 27-16 at KC | 11 | 134 | 12.2 | 2 | 25 | 0 | ||
| 3. Calvin Johnson, WR | DET | L 48-24 at CHI | 8 | 133 | 16.6 | 0 | 45 | 0 | ||
| 4. Jermichael Finley, TE | GB | L 30-23 at MIN | 6 | 128 | 21.3 | 1 | 62 | 0 | ||
| 5. Antonio Gates, TE | SD | L 38-28 at PIT | 9 | 124 | 13.8 | 2 | 30 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
D'Qwell Jackson |
1. D'Qwell Jackson, LB | CLE | L 23-20 vs. CIN | 13 | 1 | 14 | 0.0 | 1 | 0 | 0 |
| 2. Ray Lewis, LB | BAL | L 27-21 at NE | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Tommy Kelly, DT | OAK | L 29-6 at HOU | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. David Harris, LB | NYJ | L 24-10 at NO | 10 | 2 | 12 | 0.0 | 1 | 0 | 0 | |
| 5. Reed Doughty, S | WSH | W 16-13 vs. TB | 10 | 1 | 11 | 0.0 | 0 | 0 | 0 | |
