| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Peyton Manning |
1. Peyton Manning, QB | IND | W 18-14 vs. SF | 31 | 48 | 347 | 0 | 0 | 3 | 0 | 86.0 |
| 2. Drew Brees, QB | NO | W 35-27 vs. ATL | 25 | 33 | 308 | 2 | 1 | 2 | 1 | 111.7 | |
| 3. Matt Ryan, QB | ATL | L 35-27 at NO | 19 | 42 | 289 | 1 | 3 | 3 | 0 | 46.6 | |
| 4. Aaron Rodgers, QB | GB | L 38-26 vs. MIN | 26 | 41 | 287 | 3 | 0 | 6 | 0 | 108.5 | |
| 5. Matt Schaub, QB | HOU | W 31-10 at BUF | 25 | 34 | 268 | 0 | 2 | 1 | 0 | 71.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Chris Johnson |
1. Chris Johnson, RB | TEN | W 30-13 vs. JAC | 24 | 228 | 9.5 | 2 | 89 | 0 | |
| 2. Maurice Jones-Drew, RB | JAC | L 30-13 at TEN | 8 | 177 | 22.1 | 2 | 80 | 0 | ||
| 3. DeAngelo Williams, RB | CAR | W 34-21 at ARI | 23 | 158 | 6.9 | 0 | 77 | 0 | ||
| 4. Michael Turner, RB | ATL | L 35-27 at NO | 20 | 151 | 7.6 | 1 | 37 | 0 | ||
| 5. Steven Jackson, RB | STL | W 17-10 at DET | 22 | 149 | 6.8 | 1 | 26 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Reggie Wayne |
1. Reggie Wayne, WR | IND | W 18-14 vs. SF | 12 | 147 | 12.3 | 1 | 32 | 0 | |
| 2. Roddy White, WR | ATL | L 35-27 at NO | 4 | 108 | 27.0 | 1 | 68 | 0 | ||
| 3. Vincent Jackson, WR | SD | W 24-16 vs. OAK | 8 | 103 | 12.9 | 1 | 20 | 0 | ||
| 4. Dallas Clark, TE | IND | W 18-14 vs. SF | 8 | 99 | 12.4 | 0 | 40 | 0 | ||
| 5. Nate Burleson, WR | SEA | L 38-17 at DAL | 6 | 89 | 14.8 | 0 | 36 | 1 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Justin Durant |
1. Justin Durant, LB | JAC | L 30-13 at TEN | 12 | 4 | 16 | 0.0 | 0 | 0 | 0 |
| 2. George Wilson, S | BUF | L 31-10 vs. HOU | 7 | 8 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Curtis Lofton, LB | ATL | L 35-27 at NO | 12 | 2 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Karlos Dansby, LB | ARI | L 34-21 vs. CAR | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Chad Greenway, LB | MIN | W 38-26 at GB | 10 | 1 | 11 | 0.0 | 0 | 0 | 0 | |
