| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Philip Rivers |
1. Philip Rivers, QB | SD | L 17-14 vs. NYJ | 27 | 40 | 298 | 1 | 2 | 2 | 0 | 76.9 |
| 2. Drew Brees, QB | NO | W 45-14 vs. ARI | 23 | 32 | 247 | 3 | 0 | 0 | 0 | 125.4 | |
| 3. Peyton Manning, QB | IND | W 20-3 vs. BAL | 30 | 44 | 246 | 2 | 1 | 2 | 0 | 87.9 | |
| 4. Brett Favre, QB | MIN | W 34-3 vs. DAL | 15 | 24 | 234 | 4 | 0 | 3 | 0 | 134.4 | |
| 5. Kurt Warner, QB | ARI | L 45-14 at NO | 17 | 26 | 205 | 0 | 1 | 1 | 0 | 73.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Shonn Greene |
1. Shonn Greene, RB | NYJ | W 17-14 at SD | 23 | 128 | 5.6 | 1 | 53 | 0 | |
| 2. Tim Hightower, RB | ARI | L 45-14 at NO | 6 | 87 | 14.5 | 1 | 70 | 0 | ||
| 3. Reggie Bush, RB | NO | W 45-14 vs. ARI | 5 | 84 | 16.8 | 1 | 46 | 0 | ||
| 4. Felix Jones, RB | DAL | L 34-3 at MIN | 14 | 69 | 4.9 | 0 | 17 | 0 | ||
| 5. Ray Rice, RB | BAL | L 20-3 at IND | 13 | 67 | 5.2 | 0 | 20 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Sidney Rice |
1. Sidney Rice, WR | MIN | W 34-3 vs. DAL | 6 | 141 | 23.5 | 3 | 47 | 0 | |
| 2. Vincent Jackson, WR | SD | L 17-14 vs. NYJ | 7 | 111 | 15.9 | 0 | 37 | 0 | ||
| 3. Jason Witten, TE | DAL | L 34-3 at MIN | 10 | 98 | 9.8 | 0 | 22 | 0 | ||
| 4. Antonio Gates, TE | SD | L 17-14 vs. NYJ | 8 | 93 | 11.6 | 0 | 23 | 0 | ||
| 5. Marques Colston, WR | NO | W 45-14 vs. ARI | 6 | 83 | 13.8 | 1 | 26 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Dannell Ellerbe |
1. Dannell Ellerbe, LB | BAL | L 20-3 at IND | 10 | 0 | 10 | 0.0 | 0 | 0 | 0 |
| 2. Anthony Spencer, LB | DAL | L 34-3 at MIN | 9 | 1 | 10 | 1.0 | 0 | 0 | 0 | |
| 3. David Harris, LB | NYJ | W 17-14 at SD | 9 | 1 | 10 | 0.0 | 0 | 0 | 0 | |
| 4. Karlos Dansby, LB | ARI | L 45-14 at NO | 8 | 2 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Keith Brooking, LB | DAL | L 34-3 at MIN | 5 | 5 | 10 | 0.0 | 0 | 0 | 0 | |
