| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Peyton Manning |
1. Peyton Manning, QB | IND | L 31-28 at NE | 38 | 52 | 396 | 4 | 3 | 0 | 0 | 96.3 |
| 2. Drew Brees, QB | NO | W 34-19 vs. SEA | 29 | 43 | 382 | 4 | 2 | 0 | 0 | 106.9 | |
| 3. Donovan McNabb, QB | WSH | W 19-16 at TEN | 30 | 50 | 376 | 1 | 1 | 3 | 0 | 81.8 | |
| 4. Matt Hasselbeck, QB | SEA | L 34-19 at NO | 32 | 44 | 366 | 1 | 0 | 0 | 0 | 104.9 | |
| 5. Ryan Fitzpatrick, QB | BUF | W 49-31 at CIN | 21 | 34 | 316 | 4 | 2 | 1 | 0 | 107.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Maurice Jones-Drew |
1. Maurice Jones-Drew, RB | JAC | W 24-20 vs. CLE | 23 | 133 | 5.8 | 1 | 22 | 1 | |
| 2. Michael Turner, RB | ATL | W 34-17 at STL | 28 | 131 | 4.7 | 1 | 39 | 0 | ||
| 3. Chris Johnson, RB | TEN | L 19-16 vs. WSH | 21 | 130 | 6.2 | 0 | 29 | 0 | ||
| 4. Cedric Benson, RB | CIN | L 49-31 vs. BUF | 25 | 124 | 5.0 | 1 | 26 | 1 | ||
| 5. Mike Goodson, RB | CAR | L 37-13 vs. BAL | 22 | 120 | 5.5 | 0 | 45 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Greg Jennings |
1. Greg Jennings, WR | GB | W 31-3 at MIN | 7 | 152 | 21.7 | 3 | 47 | 0 | |
| 2. Steve Johnson, WR | BUF | W 49-31 at CIN | 8 | 137 | 17.1 | 3 | 36 | 0 | ||
| 3. Santonio Holmes, WR | NYJ | W 30-27 vs. HOU | 7 | 126 | 18.0 | 2 | 41 | 0 | ||
| 4. Jeremy Maclin, WR | PHI | W 27-17 vs. NYG | 9 | 120 | 13.3 | 0 | 35 | 0 | ||
| 5. Nate Washington, WR | TEN | L 19-16 vs. WSH | 5 | 117 | 23.4 | 0 | 52 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Jerod Mayo |
1. Jerod Mayo, LB | NE | W 31-28 vs. IND | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Patrick Willis, LB | SF | L 21-0 vs. TB | 9 | 4 | 13 | 2.0 | 0 | 0 | 0 | |
| 3. David Hawthorne, LB | SEA | L 34-19 at NO | 10 | 2 | 12 | 0.0 | 0 | 1 | 0 | |
| 4. Pat Angerer, LB | IND | L 31-28 at NE | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Scott Shanle, LB | NO | W 34-19 vs. SEA | 9 | 3 | 12 | 0.0 | 1 | 0 | 0 | |
