| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jon Kitna |
1. Jon Kitna, QB | DAL | L 35-17 vs. JAC | 34 | 49 | 379 | 1 | 4 | 2 | 0 | 64.9 |
| 2. Kyle Orton, QB | DEN | L 24-16 at SF | 28 | 40 | 370 | 1 | 1 | 4 | 1 | 96.9 | |
| 3. Jason Campbell, QB | OAK | W 33-3 vs. SEA | 15 | 27 | 310 | 2 | 0 | 2 | 0 | 120.9 | |
| 4. Philip Rivers, QB | SD | W 33-25 vs. TEN | 27 | 36 | 305 | 2 | 1 | 1 | 0 | 106.8 | |
| 5. Drew Brees, QB | NO | W 20-10 vs. PIT | 34 | 44 | 305 | 2 | 1 | 2 | 1 | 101.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jamaal Charles |
1. Jamaal Charles, RB | KC | W 13-10 vs. BUF | 22 | 177 | 8.0 | 0 | 32 | 0 | |
| 2. Maurice Jones-Drew, RB | JAC | W 35-17 at DAL | 27 | 135 | 5.0 | 0 | 24 | 0 | ||
| 3. LeGarrette Blount, RB | TB | W 38-35 at ARI | 22 | 120 | 5.5 | 2 | 48 | 1 | ||
| 4. Frank Gore, RB | SF | W 24-16 vs. DEN | 29 | 118 | 4.1 | 1 | 21 | 0 | ||
| 5. BenJarvus Green-Ellis, RB | NE | W 28-18 vs. MIN | 17 | 112 | 6.6 | 2 | 26 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Brandon Lloyd |
1. Brandon Lloyd, WR | DEN | L 24-16 at SF | 7 | 169 | 24.1 | 1 | 71 | 0 | |
| 2. Mike Sims-Walker, WR | JAC | W 35-17 at DAL | 8 | 153 | 19.1 | 1 | 39 | 0 | ||
| 3. Steve Breaston, WR | ARI | L 38-35 vs. TB | 8 | 147 | 18.4 | 0 | 37 | 0 | ||
| 4. Antonio Gates, TE | SD | W 33-25 vs. TEN | 5 | 123 | 24.6 | 1 | 48 | 0 | ||
| 5. Miles Austin, WR | DAL | L 35-17 vs. JAC | 7 | 117 | 16.7 | 0 | 35 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Paul Posluszny |
1. Paul Posluszny, LB | BUF | L 13-10 at KC | 11 | 6 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Jerod Mayo, LB | NE | W 28-18 vs. MIN | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Lawrence Timmons, LB | PIT | L 20-10 at NO | 11 | 1 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Justin Durant, LB | JAC | W 35-17 at DAL | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Eric Weddle, S | SD | W 33-25 vs. TEN | 10 | 1 | 11 | 0.0 | 0 | 0 | 0 | |
