| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Eli Manning |
1. Eli Manning, QB | NYG | L 36-25 vs. SEA | 24 | 39 | 420 | 3 | 3 | 3 | 1 | 91.8 |
| 2. Matt Schaub, QB | HOU | L 25-20 vs. OAK | 24 | 51 | 416 | 2 | 2 | 3 | 0 | 72.0 | |
| 3. Aaron Rodgers, QB | GB | W 25-14 at ATL | 26 | 39 | 396 | 2 | 0 | 4 | 0 | 117.0 | |
| 4. Drew Brees, QB | NO | W 30-27 at CAR | 32 | 45 | 359 | 2 | 1 | 2 | 0 | 100.1 | |
| 5. Tom Brady, QB | NE | W 30-21 vs. NYJ | 24 | 33 | 321 | 1 | 1 | 4 | 0 | 100.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jahvid Best |
1. Jahvid Best, RB | DET | W 24-13 vs. CHI | 12 | 163 | 13.6 | 1 | 88 | 0 | |
| 2. BenJarvus Green-Ellis, RB | NE | W 30-21 vs. NYJ | 27 | 136 | 5.0 | 2 | 15 | 0 | ||
| 3. Willis McGahee, RB | DEN | L 29-24 vs. SD | 16 | 125 | 7.8 | 0 | 28 | 0 | ||
| 4. Frank Gore, RB | SF | W 48-3 vs. TB | 20 | 125 | 6.3 | 1 | 21 | 1 | ||
| 5. Ryan Mathews, RB | SD | W 29-24 at DEN | 24 | 125 | 5.2 | 0 | 36 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Victor Cruz |
1. Victor Cruz, WR | NYG | L 36-25 vs. SEA | 8 | 161 | 20.1 | 1 | 68 | 1 | |
| 2. James Jones, WR | GB | W 25-14 at ATL | 5 | 140 | 28.0 | 1 | 70 | 0 | ||
| 3. Jason Avant, WR | PHI | L 31-24 at BUF | 9 | 139 | 15.4 | 0 | 35 | 1 | ||
| 4. Doug Baldwin, WR | SEA | W 36-25 at NYG | 8 | 136 | 17.0 | 1 | 27 | 0 | ||
| 5. Calvin Johnson, WR | DET | W 24-13 vs. CHI | 5 | 130 | 26.0 | 1 | 73 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Pat Angerer |
1. Pat Angerer, LB | IND | L 28-24 vs. KC | 4 | 11 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Jason McCourty, CB | TEN | L 38-17 at PIT | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Nate Allen, S | PHI | L 31-24 at BUF | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. James Farrior, LB | PIT | W 38-17 vs. TEN | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. DeAndre Levy, LB | DET | W 24-13 vs. CHI | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
