Vanek says he feels ready to play after skating Tuesday for the first time since sustaining a head injury in a 5-3 preseason win at Montreal last week. Lalime has been bothered by a groin injury.
Coach Lindy Ruff said there's a good chance for both players to be cleared to play Friday, when Buffalo opens at Ottawa.
Defenseman Craig Rivet has also been cleared to play after hurting his neck in practice on Sept. 24.
Ruff also said the Sabres waived fourth-line forward Matt Ellis, who will report to the minors if not claimed by another team.