Atlanta (1-2-0) is averaging 31.0 shots but has been outshot by 3.0 per game.
"Getting 30-plus shots a game is definitely key for us," Kane said Tuesday. "I thought we had some quality chances tonight, but we gave up some quality chances, too, which we can't do. If we're getting 30 shots, we can't have the other team getting 30 shots."
The Thrashers' new lines will likely take aim at Jonas Hiller, who has faced a league-high 165 shots.
Hiller and the Ducks' struggling defense could receive a boost Friday with the first appearance of free-agent signee Toni Lydman, who has been cleared after missing the entire preseason with double vision.
Signed to a one-year deal Monday to counter the loss of fellow newcomer Andy Sutton (broken right thumb), veteran defenseman Andreas Lilja could make his Anaheim debut pending visa issues.
While coach Randy Carlyle is hoping the Ducks (1-3-0) improve on defense, his club's top line stepped up after the team scored just two goals during its 0-3-0 start.
With no goals and a minus-12 rating during that skid, captain Ryan Getzlaf, Corey Perry and Bobby Ryan combined for three goals and four assists in Wednesday's 4-3 home-opening victory against Vancouver.
"We know we've got to score and be effective," Getzlaf said after scoring once and adding three assists for his fifth career four-point game. "It was time for that."
Getzlaf and Perry have no goals in three career games against Atlanta, while Ryan has a goal and two assists in this matchup.
Anaheim will get its first look at goaltender Chris Mason in a Thrashers uniform. Mason, who played the last two seasons with St. Louis, has been starting in net since Ondrej Pavelec collapsed on the ice 2 1/2 minutes into last Friday's season-opening win over Washington.
Mason made 23 saves in his last matchup against the Ducks -- a 6-3 win on April 9. He was 0-4-1 with a 3.20 GAA in his previous five starts versus Anaheim.
Ducks forward Teemu Selanne scored his first goal of the season Wednesday and is one shy of tying Dino Ciccarelli for 16th all-time with 608. Selanne found the back of the net twice and recorded an assist in the teams' last matchup at Honda Center, an 8-4 Thrashers victory on Feb. 15, 2009.