Kris Russell and Rick Nash added goals for Columbus, which improved to 2-2 in the preseason. Clarke MacArthur scored for Buffalo, in its first preseason game.
Steve Mason stopped 20 shots for Columbus. Buffalo goalie Jocelyn Thibault, the Sabres' lone free-agent signing of the offseason, made 18 saves.
Russell and Brule scored power-play goals 25 seconds apart in the second period to give the Blue Jackets a 2-0 lead. Columbus started the second period with a two-man advantage carried over from the first period, and Russell scored 49 seconds in on a deflection. Brule then snapped in a shot from the left faceoff circle with 1 second remaining in the power play.
Nash scored six minutes into the third, backhanding in a loose puck after Thibault stopped Rostislav Klesla on a backhand shot. Brule netted his second of the night six minutes later on a tip-in.
Copyright by STATS LLC and The Associated Press
Arena: First Niagara Center Location: Buffalo, New York
No scoring this period
Kris Russell (power play) Assist: Derrick Brassard, Sergei Fedorov
Gilbert Brule (power play) Assist: Jakub Voracek, Duvie Westcott
Rick Nash Assist: Rostislav Klesla, Jason Chimera
Clarke MacArthur Assist: Michael Funk, Dylan Hunter
Gilbert Brule (power play) Assist: Duvie Westcott, Jason Chimera