Tallinder opened the scoring at 1:24. Stafford made it 2-0 with a power-play goal at 7:52.
Pominville converted a cross-ice pass from Clarke MacArthur 37 seconds into the second period, and Vanek made it 4-0 at 1:12 with a slider that went through Staffan Kronwall's legs and then Toskala's legs.
Roy then went to work, scoring at 17:08 while Buffalo had a two-man advantage. He added his second goal early in the third period and finished the scoring with a short-handed goal at 6:30.
Copyright by STATS LLC and The Associated Press
Arena: Air Canada Centre Location: Toronto, Ontario
Henrik Tallinder Assist: Derek Roy, Ales Kotalik
Drew Stafford (power play) Assist: Derek Roy, Thomas Vanek
Jason Pominville Assist: Clarke MacArthur, Brian Campbell
Thomas Vanek Assist: Derek Roy, Toni Lydman
Pavel Kubina (shorthanded) Assist: Matt Stajan
Chad Kilger Assist: John Pohl, Hal Gill
Derek Roy (power play) Assist: Drew Stafford, Thomas Vanek