"It feels really good, but it's one game," Mason said. "It seemed like a long stretch when you forget what winning's like a little bit."
He posted victories in Nashville's first two games this season, then went into his slide.
"Mace needed a win and we're glad he got it," said David Legwand, who opened the scoring just 1:23 into the game as Nashville jumped out a 3-1 lead in the first period.
"Chris Mason was outstanding tonight," Predators coach Barry Trotz added.
The Predators, who climbed back to .500 with the victory, are 6-0 this season when they score first.
"It felt really good [to get the early lead]," Mason said. "I don't know if we're going to win every game this season when we score first, but we haven't lost one yet."
"We're going to change something up," Blackhawks coach Denis Savard said. "We've got to have urgency every shift, every battle. And if you don't this is what happens in this league."
Nikolai Khabibulin started in goal for the Blackhawks, but allowed three goals on six shots in the first period and was replaced by Patrick Lalime to start the second. He gave up one goal on 12 shots.
"He's [Khabibulin] not the only one to be blamed," Savard said. "Those first three goals, there's not much he could do about it... wish we could get one save with those three chances."
Nashville's final goal, by Arnott, was scored into an empty net.
Legwand and Radulov had goals 1:58 apart on Nashville's first two shots to give the Predators a 2-0 advantage.
Lang cut it to 2-1 at 9:43 of the first with the Blackhawks using a 5-on-3 advantage.
Perreault scored his first goal for Chicago at 9:23 of the second to make it 3-2.
Tootoo extended the lead back to two goals picking off a blind pass by Blackhawks defenseman James Wisniewski at the Chicago blue line. Tootoo's shot from the left circle struck Lalime's arm and trickled in.
Arnott completed the scoring goal with an empty-net power-play goal with 46.2 seconds left.
Nashville LW Martin Gelinas sat out his sixth game with a bruised shoulder and is day-to-day. ... LW Darcy Hordichuk missed his fifth game with a broken toe and will remain out for at least a week. ... Chicago LW Sergei Samsonov was a healthy scratch for the fourth straight game.