Osgood had a rough night, giving up a goal on the first shot he faced and allowing a season-high five goals shortly after he was named an All-Star and one day following the announcement of his three-year contract.
"Things had been going so well for me and the team," said Osgood, who had 23 saves. "I've had some lucky breaks and so have we, but this was the first time all year that the puck was ricocheting around and going in our net."
Backstrom was pulled after giving up four goals on 19 shots, including Niklas Kronwall's tying goal at 8:38 of the second period.
Harding kept the Wild in the game, turning away a slew of shots, including two quality scoring chances Pavel Datsyuk had in the third and stopping him and Henrik Zetterberg in the shootout.
"It was a busy day, winning a game against this team, which we don't do too often, and getting new owners," Lemaire said. "It's a big day."
The new owner had to like the results of his first game, beating a team that entered the matchup 20-3-2 since mid-November.
Detroit began the day with at least 10 more points than any team in the NHL and were playing a team that had lost two straight on the road.
"Every once in a while you need a reminder in life that you've got to work hard and you've got to work for 60 minutes," Red Wings coach Mike Babcock said.
Skoula had a goal 4-plus minutes into the game. Zetterberg then scored for the 27th time, but the Wild had two goals in a 15-second span to go ahead by two goals for the first of two times. Filppula pulled Detroit to 3-2 in the final minute of the opening period.
Foy scored early in the second period, then the Red Wings overcame a two-goal deficit again with Drake's short-handed goal and Kronwall's goal in a 1:06 span.
"We haven't had one of those for ages," Osgood said. "We aren't used to those kind of run-and-gun games. We were down twice, didn't shut it down, kept fighting back. That was a good."
Minnesota beat Detroit for just the seventh time in 27 meetings since entering the league during the 2000-01 season. The Red Wings won the first two meetings this season by a combined score of 9-1.
"We don't win here very often. I don't think any team does," Nick Schultz said. "It's one of the hardest buildings to play in and they are the elite team in the league now."
Osgood entered the game giving up an NHL-low 1.7 goals a game and tying the league high with a .932 save percentage and no one could compare to his 19-2-1 record. He had allowed four goals only once before this season, winning the game in a shootout on Nov. 18 at Columbus. ... Mikko Koivu (broken leg) is expected to play for the first time since mid-November on Friday night in Chicago.