After Zagrapan opened the scoring on a power play just 45 seconds in, the Maple Leafs found their stride and dominated much of the period. Moore tied it at 8:09 after a strong forecheck caused a Sabres turnover and the Leafs center beat Sabres goalie Ryan Miller over the shoulder.
Colaiacovo put the Leafs ahead for good at 18:51 when his shot found its way through a crowd and behind Miller.
Goaltender Curtis Joseph, who returned to the Maple Leafs as a free agent over the summer, played the first period and stopped four of the five shots he faced. Fans chanted his name before the game -- his first in a Maple Leafs jersey in more than six years.
Copyright by STATS LLC and The Associated Press
Arena: Air Canada Centre Location: Toronto, Ontario
Attendance: 18,819 (100.1% full)
Marek Zagrapan (power play) Assist: Andrej Sekera, Clarke MacArthur
Dominic Moore Unassisted
Carlo Colaiacovo Unassisted
Boyd Devereaux Assist: Mark Bell, Carlo Colaiacovo
Robert Earl Assist: Ian White, Jason Blake
Philip Gogulla (power play) Assist: Clarke MacArthur, Marek Zagrapan
Matt Stajan (power play) Assist: Jason Blake, Jiri Tlusty
Mark Mancari Assist: Marek Zagrapan, Jaroslav Spacek
Dominic Moore Assist: Ben Ondrus, Jeff Finger
Jochen Hecht (power play) Assist: Drew Stafford, Ales Kotalik