Kronwall had a power-play goal in the first and Detroit added two more in the second.
The Red Wings dominated play in the first, outshooting the Oilers 16-9.
"It's sad that when we're down just 1-0 after the first period," said Shawn Horcoff. "... We should be able to build off of that."
But Samuelsson tipped in Brett Lebda's pass out of the corner for his fourth of the season and Hudler's pass from the right circle deflected in off the leg of Edmonton defenseman Sheldon Souray at 14:18.
"The difference was the second period. We have five or six red-zone chances where it's just us and the goalie and we don't hit the net," said Edmonton coach Craig MacTavish. "And then Samuelsson scores for them to make it 2-0 and then they get another goal and the game was over."
Franzen added his ninth goal with 9:56 left in the game. He has scored in each of the last four games after missing five contests with a knee injury. He also scored in the game in which he was injured for a five-game goal streak.
Dating back to last season and including the playoffs, Franzen has 37 goals in his last 44 games.
"I got a good start coming back from injury," he said. "I've been scoring every game. That helps the legs feel lighter because I'm not 100 percent yet skating-wise."
Detroit's offense was more than enough for Conklin, who played for the Oilers for three seasons.
Detroit forward Dan Cleary was sidelined with an eye infection. ... Edmonton forward Dustin Penner was a healthy scratch for the second consecutive game. ... Oilers center Fernando Pisani broke his ankle as he slid into the boards feet first as he battled for the puck with the Red Wings' Nicklas Lidstrom with a little under 15 minutes left in the third period. MacTavish said that Pisani, who was on crutches after the game, would be out at least a month.
Copyright by STATS LLC and The Associated Press
Arena: Joe Louis Arena Location: Detroit, Michigan
Referees: Paul Devorski, Eric Furlatt Linesmen: Jean Morin, David Brisebois
Attendance: 18,934 (94.4% full)
Team Stat Comparison
Power Play Goals
Power Play Opportunities
Shots on Goal
Niklas Kronwall (2)
(Power Play) Assists: Henrik Zetterberg, Jiri Hudler
Mikael Samuelsson (4)
Assists: Brett Lebda, Henrik Zetterberg
Jiri Hudler (4)
Assists: Valtteri Filppula, Andreas Lilja
Johan Franzen (9)
Assists: Brad Stuart, Niklas Kronwall