The Canucks scored three times in the game's first 9 minutes and took a 5-0 lead into the third period.
Vancouver starting goalie Andrew Raycroft stopped the first 22 shots he faced while Sharks' starter Thomas Greiss appeared overwhelmed, allowing five goals among the 14 shots he faced. Alex Stalock, who had 11 saves, took over midway through the second period.
Mitchell took advantage of traffic in front of the net midway through the first period. He slapped the puck into the upper right corner from just inside the blue line.
Just over a minute later, Alex Burrows dug the puck out of the corner and backhanded a pass to Scatchard, who beat Greiss.
Daniel Sedin made it 3-0 less than 2 minutes later, finding the open net after redirecting Henrik's shot.
Daniel led the Canucks with 31 goals last season while Henrick was the team leader with 60 assists. They tied for the team lead with 82 points each.
Hinote got the Sharks on the scoreboard 4 minutes into the third period by picking up Nicholas Petrecki's deflection.
Ehrhoff, a former Sharks' fan favorite, was not well received when he scored Vancouver's final goal on a slap shot from long range.
McGinn ended the scoring with his follow on Patrick Marleau's blocked shot.
Copyright by STATS LLC and The Associated Press
Arena: SAP Center Location: San Jose, California
Attendance: 15,782 (90.2% full)
Willie Mitchell Assist: Sergei Shirokov
Cody Hodgson Assist: Alexandre Burrows, Michael Grabner
Daniel Sedin (power play) Assist: Henrik Sedin, Sergei Shirokov
Henrik Sedin Unassisted
Henrik Sedin (power play) Assist: Daniel Sedin, Christian Ehrhoff
Jed Ortmeyer Assist: Nick Petrecki, Patrick Marleau
Christian Ehrhoff Assist: Daniel Sedin, Henrik Sedin