"We needed two points. All you've got to do is look at the standings," Red Wings coach Mike Babcock said. "We're trying to do everything we can to hang in there."
Bertuzzi beat Jean-Sebastien Giguere high on the short side from the bottom of the right circle, as he skated from behind the net, in overtime.
"I think it's just being in the league for a while and knowing goaltenders and playing with Giggy," Bertuzzi said, "and knowing he likes to hug the post. There's not a lot of room up there but just enough to squeak it in."
Saku Koivu and Dan Sexton each had a goal and an assist for Anaheim, and Giguere made 28 saves. The Ducks have lost nine straight on the road. They also took 11 penalties on Friday night.
"We took way too many penalties the entire game," Sexton said. "Five-on-five we had them pretty good."
Bertuzzi tied it at 2 at 9:36 of the third, banking a shot in off Giguere's skate from the right corner.
Holmstrom's power-play goal 2:17 into the third put Detroit on the board. He put in a one-time shot from the slot for his 12th goal and broke the Red Wings' 102:24 overall scoreless drought and 142:18 dry spell at Joe Louis Arena.
It came 36 seconds after Ahaheim's Ryan Getzlaf took a hooking penalty deep in the Red Wings' zone.
"We had a 2-0 lead going into the third period and in the first two minutes we take an offensive zone penalty 200 feet from our net," Ducks coach Randy Carlyle said. "And then take an unsportsmanlike conduct penalty [by Nick Boynton at 4:46]. ... How can you have a 2-0 lead with those kind of penalties? Just self-destructed."
Anaheim took a 2-0 lead in the second period.
Koivu opened the scoring at 8:05 of the middle period with his fifth goal when he tipped in Sexton's pass. Sexton's goal came with 55 seconds left in the second when his harmless looking shot from the right corner deflected in off Howard's stick.
It was Sexton's third goal.
NHL commissioner Gary Bettman said Friday it was unfortunate that Ducks owner Dr. Henry Samueli had to endure a suspension after he pleaded guilty last year to lying to investigators in a stock option backdating probe. A federal judge in Santa Ana, Calif., vacated Samueli's guilty plea earlier this week after the judge found no evidence of wrongdoing. The suspension, in place since June 2008, was lifted Nov. 12, before Samueli's plea was vacated. ... Cleary missed his first game after separating a shoulder Wednesday night against St. Louis. He is expected to miss about a month. ... The jumbotron scoreboard wasn't working for the first half of the first period. ... Sexton has three goals in his last two games, his second and third in the NHL.