T.J. Oshie scored a power-play goal for his first score of the preseason. Brad Boyes added an empty-net goal and an assist, and Erik Johnson had an assist for St. Louis (3-2-0).
The Blues killed off five of six power plays.
Johnson skated off the ice with 1:39 left in the first period after taking a puck to the left cheek. He returned at the start of the second period.
Craig Anderson was tested more than Bishop. Anderson stopped 35 of 37 shots for Colorado (1-3-0).
The Avalanche beat the Blues 3-1 on Sept. 21 in St. Louis.
Bishop had 12 saves in the first period as the Blues took a 1-0 lead. Oshie took a pass in the high slot from Boyes and beat Anderson stick side at 7:14 of the period.
St. Louis missed a chance to extend its lead, when it had a two-man advantage for 1:35 beginning at 7:29 of the second period. Bishop maintained the shutout batting away Paul Stastny's shot off a 2-on-1 break in the last 2 minutes of the period.
Bishop caught a one-timer by Milan Hejduk at the start of the third period.
Colorado pulled Anderson with 1:25 remaining, but never put a shot on goal. Boyes tapped in an empty-netter with 42 seconds left.
Copyright by STATS LLC and The Associated Press
Arena: Pepsi Center Location: Denver, Colorado
Referees: Brad Watson, Francois St. Laurent Linesmen: Don Henderson, Jay Sharrers
T.J. Oshie 1 (power play) Assist: Brad Boyes, Erik Johnson