Pavel Datsyuk had a goal and an assist and Mike Modano also scored for Detroit, his first in a Red Wings uniform after signing a $1.25 million free-agent contract in ealy August. Chris Osgood stopped 20 shots.
"We've got to play a lot better than we did tonight and we expect to do that," Detroit coach Mike Babcock said.
Sidney Crosby and defenseman Brooks Orpik sat out for Pittsburgh. Orpik missed the game and the trip because of a groin injury.