Rice drove last year for Rahal Letterman Racing. The 2004 Indianapolis 500 winner will drive the No. 15 car, competing in his sixth year of the IndyCar Series, at Homestead-Miami Speedway on March 24.
Fisher, 26, will drive No. 5 for team co-owner Dennis Reinbold, who first put Fisher in his car in 2002.
Fisher's most recent races in the IndyCar series came last year in the Meijer Indy 400 at the Kentucky Speedway (12th) and the Peak AntiFreeze Indy 300 at the Chicagoland Speedway (16th) in Chicago.
"Coming back the last two races last year really made me realize how much I've missed it," said Fisher, who will compete part-time while pursuing a business degree. "Things have changed a little bit since I've been gone, but I'm up for the challenge."
Fisher finished second at Homestead-Miami Speedway in 2000 and third at the Kentucky Speedway in 2001, giving her the best two finishes by a woman. She is the fastest women to qualify for the Indy 500 at 229.439 mph.